Temporal signaling and differential expression of Bordetella iron transport systems: The role of ferrimones and positive regulators

Timothy J. Brickman; Sandra K. Armstrong

doi:10.1007/s10534-008-9189-9

Temporal signaling and differential expression of Bordetella iron transport systems: The role of ferrimones and positive regulators

Timothy J. Brickman
, Sandra K. Armstrong

Microbiology

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

The bacterial respiratory pathogens Bordetella pertussis and Bordetella bronchiseptica employ multiple alternative iron acquisition pathways to adapt to changes in the mammalian host environment during infection. The alcaligin, enterobactin, and heme utilization pathways are differentially expressed in response to the cognate iron source availability by a mechanism involving substrate-inducible positive regulators. As inducers, the iron sources function as chemical signals termed ferrimones. Ferrimone-sensing allows the pathogen to adapt and exploit early and late events in the infection process.

Original language	English (US)
Pages (from-to)	33-41
Number of pages	9
Journal	BioMetals
Volume	22
Issue number	1
DOIs	https://doi.org/10.1007/s10534-008-9189-9
State	Published - Feb 2009

Bibliographical note

Funding Information:
subject to interference or signal antagonism. All three circuits converge to supply the requisite nutrient iron. When the bacterium’s iron demands are satisfied, iron activates the DNA-binding activity of the Fur repressor and iron transport system expression is globally repressed Acknowledgements The authors’ research described herein was supported by Public Health Service grant AI-31088 from the National Institute of Allergy and Infectious Diseases.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Bordetella
Ferrimone
Heme
Iron
Regulation
Siderophore

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10.1007/s10534-008-9189-9

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title = "Temporal signaling and differential expression of Bordetella iron transport systems: The role of ferrimones and positive regulators",

abstract = "The bacterial respiratory pathogens Bordetella pertussis and Bordetella bronchiseptica employ multiple alternative iron acquisition pathways to adapt to changes in the mammalian host environment during infection. The alcaligin, enterobactin, and heme utilization pathways are differentially expressed in response to the cognate iron source availability by a mechanism involving substrate-inducible positive regulators. As inducers, the iron sources function as chemical signals termed ferrimones. Ferrimone-sensing allows the pathogen to adapt and exploit early and late events in the infection process.",

keywords = "Bordetella, Ferrimone, Heme, Iron, Regulation, Siderophore",

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note = "Funding Information: subject to interference or signal antagonism. All three circuits converge to supply the requisite nutrient iron. When the bacterium{\textquoteright}s iron demands are satisfied, iron activates the DNA-binding activity of the Fur repressor and iron transport system expression is globally repressed Acknowledgements The authors{\textquoteright} research described herein was supported by Public Health Service grant AI-31088 from the National Institute of Allergy and Infectious Diseases.",

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doi = "10.1007/s10534-008-9189-9",

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AU - Armstrong, Sandra K.

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N2 - The bacterial respiratory pathogens Bordetella pertussis and Bordetella bronchiseptica employ multiple alternative iron acquisition pathways to adapt to changes in the mammalian host environment during infection. The alcaligin, enterobactin, and heme utilization pathways are differentially expressed in response to the cognate iron source availability by a mechanism involving substrate-inducible positive regulators. As inducers, the iron sources function as chemical signals termed ferrimones. Ferrimone-sensing allows the pathogen to adapt and exploit early and late events in the infection process.

AB - The bacterial respiratory pathogens Bordetella pertussis and Bordetella bronchiseptica employ multiple alternative iron acquisition pathways to adapt to changes in the mammalian host environment during infection. The alcaligin, enterobactin, and heme utilization pathways are differentially expressed in response to the cognate iron source availability by a mechanism involving substrate-inducible positive regulators. As inducers, the iron sources function as chemical signals termed ferrimones. Ferrimone-sensing allows the pathogen to adapt and exploit early and late events in the infection process.

KW - Bordetella

KW - Ferrimone

KW - Heme

KW - Iron

KW - Regulation

KW - Siderophore

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Temporal signaling and differential expression of Bordetella iron transport systems: The role of ferrimones and positive regulators

Abstract

Bibliographical note

UN SDGs

Keywords

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