Temporal patterns of recovery across eating disorder subtypes

Ann Von Holle; Andréa Poyastro Pinheiro; Laura M. Thornton; Kelly L. Klump; Wade H. Berrettini; Harry Brandt; Steven Crawford; Scott Crow; Manfred M. Fichter; Katherine A. Halmi; Craig Johnson; Allan S. Kaplan; Pamela Keel; Maria La Via; James Mitchell; Michael Strober; D. Blake Woodside; Walter H. Kaye; Cynthia M. Bulik

doi:10.1080/00048670701787610

Temporal patterns of recovery across eating disorder subtypes

Ann Von Holle, Andréa Poyastro Pinheiro, Laura M. Thornton, Kelly L. Klump, Wade H. Berrettini, Harry Brandt, Steven Crawford, Scott Crow, Manfred M. Fichter, Katherine A. Halmi, Craig Johnson, Allan S. Kaplan, Pamela Keel, Maria La Via, James Mitchell, Michael Strober, D. Blake Woodside, Walter H. Kaye, Cynthia M. Bulik

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

Objective: To compare patterns of recovery in individuals with index episodes of anorexia nervosa (AN) and bulimia nervosa (BN). Method: Using Kaplan-Meier methods and Cox proportional hazards models, comparisons were conducted that were conditional on duration of eating disorder from onset and included a conservative recovery criterion of 3 asymptomatic years. Data collection was retrospective and from two of the international Price Foundation genetic studies on 901 individuals with eating disorders. Results: Using Kaplan-Meier methods, 11% of those with index AN and 10% of those with index BN met recovery criteria at 10 years. At 15 years, 16% of those with index AN and 25% of those with index BN met recovery criteria. In a Cox proportional hazards model the index BN group had three times the rate of recovery at 10-14 years (p=0.01) than the index AN group. Conclusions: Initially the probability of recovery was greater for those with index AN, but as the duration of the eating disorder lengthened those with BN had higher probabilities of recovery. Replication of these results with prospective data using similarly stringent recovery criteria and methods is required to confirm trends.

Original language	English (US)
Pages (from-to)	108-117
Number of pages	10
Journal	Australian and New Zealand Journal of Psychiatry
Volume	42
Issue number	2
DOIs	https://doi.org/10.1080/00048670701787610
State	Published - Feb 2008

Bibliographical note

Funding Information:
The authors thank the Price Foundation for the support of the clinical collection of participants and support of data analysis. The authors acknowledge the staff of the Price Foundation Collaborative Group for their efforts in participant screening and clinical assessments, and are indebted to the participating families for their contribution of time and effort in support of this study. The present study was also supported by grant MH-66117 from the National Institutes of Health, Bethesda, MD, USA.

Keywords

Eating disorders
Recovery
Remission

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10.1080/00048670701787610

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Von Holle, A., Pinheiro, A. P., Thornton, L. M., Klump, K. L., Berrettini, W. H., Brandt, H., Crawford, S., Crow, S., Fichter, M. M., Halmi, K. A., Johnson, C., Kaplan, A. S., Keel, P., La Via, M., Mitchell, J., Strober, M., Woodside, D. B., Kaye, W. H., & Bulik, C. M. (2008). Temporal patterns of recovery across eating disorder subtypes. Australian and New Zealand Journal of Psychiatry, 42(2), 108-117. https://doi.org/10.1080/00048670701787610

Von Holle, A, Pinheiro, AP, Thornton, LM, Klump, KL, Berrettini, WH, Brandt, H, Crawford, S, Crow, S, Fichter, MM, Halmi, KA, Johnson, C, Kaplan, AS, Keel, P, La Via, M, Mitchell, J, Strober, M, Woodside, DB, Kaye, WH & Bulik, CM 2008, 'Temporal patterns of recovery across eating disorder subtypes', Australian and New Zealand Journal of Psychiatry, vol. 42, no. 2, pp. 108-117. https://doi.org/10.1080/00048670701787610

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abstract = "Objective: To compare patterns of recovery in individuals with index episodes of anorexia nervosa (AN) and bulimia nervosa (BN). Method: Using Kaplan-Meier methods and Cox proportional hazards models, comparisons were conducted that were conditional on duration of eating disorder from onset and included a conservative recovery criterion of 3 asymptomatic years. Data collection was retrospective and from two of the international Price Foundation genetic studies on 901 individuals with eating disorders. Results: Using Kaplan-Meier methods, 11% of those with index AN and 10% of those with index BN met recovery criteria at 10 years. At 15 years, 16% of those with index AN and 25% of those with index BN met recovery criteria. In a Cox proportional hazards model the index BN group had three times the rate of recovery at 10-14 years (p=0.01) than the index AN group. Conclusions: Initially the probability of recovery was greater for those with index AN, but as the duration of the eating disorder lengthened those with BN had higher probabilities of recovery. Replication of these results with prospective data using similarly stringent recovery criteria and methods is required to confirm trends.",

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note = "Funding Information: The authors thank the Price Foundation for the support of the clinical collection of participants and support of data analysis. The authors acknowledge the staff of the Price Foundation Collaborative Group for their efforts in participant screening and clinical assessments, and are indebted to the participating families for their contribution of time and effort in support of this study. The present study was also supported by grant MH-66117 from the National Institutes of Health, Bethesda, MD, USA. ",

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AU - Von Holle, Ann

AU - Pinheiro, Andréa Poyastro

AU - Thornton, Laura M.

AU - Klump, Kelly L.

AU - Berrettini, Wade H.

AU - Brandt, Harry

AU - Crawford, Steven

AU - Crow, Scott

AU - Fichter, Manfred M.

AU - Halmi, Katherine A.

AU - Johnson, Craig

AU - Kaplan, Allan S.

AU - Keel, Pamela

AU - La Via, Maria

AU - Mitchell, James

AU - Strober, Michael

AU - Woodside, D. Blake

AU - Kaye, Walter H.

AU - Bulik, Cynthia M.

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PY - 2008/2

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N2 - Objective: To compare patterns of recovery in individuals with index episodes of anorexia nervosa (AN) and bulimia nervosa (BN). Method: Using Kaplan-Meier methods and Cox proportional hazards models, comparisons were conducted that were conditional on duration of eating disorder from onset and included a conservative recovery criterion of 3 asymptomatic years. Data collection was retrospective and from two of the international Price Foundation genetic studies on 901 individuals with eating disorders. Results: Using Kaplan-Meier methods, 11% of those with index AN and 10% of those with index BN met recovery criteria at 10 years. At 15 years, 16% of those with index AN and 25% of those with index BN met recovery criteria. In a Cox proportional hazards model the index BN group had three times the rate of recovery at 10-14 years (p=0.01) than the index AN group. Conclusions: Initially the probability of recovery was greater for those with index AN, but as the duration of the eating disorder lengthened those with BN had higher probabilities of recovery. Replication of these results with prospective data using similarly stringent recovery criteria and methods is required to confirm trends.

AB - Objective: To compare patterns of recovery in individuals with index episodes of anorexia nervosa (AN) and bulimia nervosa (BN). Method: Using Kaplan-Meier methods and Cox proportional hazards models, comparisons were conducted that were conditional on duration of eating disorder from onset and included a conservative recovery criterion of 3 asymptomatic years. Data collection was retrospective and from two of the international Price Foundation genetic studies on 901 individuals with eating disorders. Results: Using Kaplan-Meier methods, 11% of those with index AN and 10% of those with index BN met recovery criteria at 10 years. At 15 years, 16% of those with index AN and 25% of those with index BN met recovery criteria. In a Cox proportional hazards model the index BN group had three times the rate of recovery at 10-14 years (p=0.01) than the index AN group. Conclusions: Initially the probability of recovery was greater for those with index AN, but as the duration of the eating disorder lengthened those with BN had higher probabilities of recovery. Replication of these results with prospective data using similarly stringent recovery criteria and methods is required to confirm trends.

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Temporal patterns of recovery across eating disorder subtypes

Abstract

Bibliographical note

Keywords

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