Temporal cell-mediated immune responses of cattle following experimental and natural exposure to living Brucella abortus.

J. M. Kaneene, R. D. Angus, D. W. Johnson, C. C. Muscoplat, R. K. Anderson, D. E. Pietz

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

A study on cell-mediated immune responses in cattle with different exposure experiences to Brucella abortus was conducted by an in vitro lymphocyte stimulation assay. The purpose of this study was to determine how soon the cell-mediated immune responses would be detected following experimental exposure to B. abortus and to study the cell-mediated immune trend following experimental and natural exposure of cattle to B. abortus. The first positive cell-mediated immune responses occurred one to two weeks after experimental inoculation with living B. abortus strain 2308. The cell-mediated immune responses in these animals appeared at least one week before the appearance of of B. abortus serum agglutinating antibodies. Animals which were naturally infected with B. abortus biotypes 1 and 2 demonstrated positive cell-mediated immune responses throughout the study.

Original languageEnglish (US)
Pages (from-to)132-141
Number of pages10
JournalCanadian Journal of Comparative Medicine
Volume43
Issue number2
StatePublished - Apr 1 1979

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