Temporal associations among energy intake, plasma linoleic acid, and growth improvement in response to treatment initiation after diagnosis of cystic fibrosis

Suzanne M. Shoff, Hong Yup Ahn, Lisa Davis, Hui Chuan Lai, Jeff Douglas, Norman Fost, Christopher Green, Ronald Gregg, Michael Kosorok, Ronald Laessig, Mari Palta, Michael Rock, Margie Rosenberg, Audrey Tluezek, L. J. Wei, Susan West, Benjamin Wilfond, W. Theodore Bruns, William Gershan, Elaine MischlerMark Splaingard, Lee Rusakow

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

OBJECTIVE. It is unclear why some patients with cystic fibrosis (CF) succeed ("responders") in recovering from malnutrition and growth faltering after treatment initiation whereas others fail to do so ("nonresponders"). We conducted a study to test the hypothesis that sustained high energy intake (↑EN) and normal plasma essential fatty acid status are critical determinants of treatment responsiveness within 2 years after diagnosis of CF. METHODS. A total of 71 CF children who had pancreatic insufficiency but not meconium ileus and were enrolled in the Wisconsin CF Neonatal Screening Project were studied. Responders were defined by having achieved adequate weight gain, as indicated by a recovery of weight z score (Wtz) comparable to Wtz at birth (WtzBR) within 2 years of diagnosis. ↑EN and sustained normal plasma linoleic acid level (↑pLA) were defined by achieving energy intake ≥120% of estimated requirement for ≥75% of the time and maintaining plasma LA ≥26% of total fatty acids for ≥75% of the time, respectively. RESULTS. Thirty-two (68%) screened patients and 13 (54%) patients whose CF was diagnosed conventionally recovered WtzBR within 2 years of diagnosis. Screened patients responded at significantly younger ages (mean/median: 6.3/4.3 months) than patients whose CF was diagnosed conventionally (mean/median: 15.8/11.8 months). Proportionately fewer screened patients (33%) achieved ↑EN compared with patients whose CF was diagnosed conventionally (73%). However, more screened patients responded to ↑EN and recovered WtzBR (91%) than patients whose CF was diagnosed conventionally (56%), although this difference was of borderline significance. Compared with having neither ↑EN nor ↑pLA, the likelihood of being a responder was greatest with combined ↑EN and ↑pLA, followed by ↑EN only. The positive associations between ↑EN and ↑pLA to treatment responsiveness remained significant after adjustment for neonatal screening status, baseline height and weight status, and indices of pulmonary disease severity. CONCLUSION. ↑EN and ↑pLA are critical in promoting adequate weight gain in children with newly diagnosed CF.

Original languageEnglish (US)
Pages (from-to)391-400
Number of pages10
JournalPediatrics
Volume117
Issue number2
DOIs
StatePublished - Feb 2006

Keywords

  • Cystic fibrosis
  • Diet
  • Energy intake
  • Growth
  • Height
  • Linoleic acid
  • Malnutrition
  • Neonatal screening
  • Prospective study
  • Weight

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