Temporal analysis of fibroblast traction and migration in tissue equivalents

David Shreiber, Victor Barocas, Paul Enever, Mihir Wagle, Robert Tranquillo

Research output: Contribution to journalConference articlepeer-review


Experimental methods and complementary theoretical methods were developed to estimate the two primary biomechanical phenomena with two parameters, for cells in tissue equivalents assuming μ and τ0 were constant in value over time. Temporal data was determined by generating mean squared displacement (MSD) data with a generalized least squares analysis. The FEM was based on the anistropic biphasic theory for tissue equivalents, and was solved with the Control and Optimization (COOPT) software package. COOPT solves a differential-algebraic equation system with piecewise polynomials that were functions of time, allowing the time dependence of 60 for the optimal fit of the compaction data to be obtained.

Original languageEnglish (US)
Pages (from-to)S-87
JournalAnnals of Biomedical Engineering
Issue numberSUPPL. 1
StatePublished - Dec 1 2000
Event2000 Annual Fall Meeting of the Biomedical Engineering Society - Washington, WA, USA
Duration: Oct 12 2000Oct 14 2000


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