Temperature Sensitivity of Angiotensin-Induced Inotropic Effects

George J. Trachte, Michael J. Peach

Research output: Contribution to journalArticle


Temperatures in the range of 30 to 37°C were examined for effects on angiotensin (Ang) peptide-induced inotropic actions in rabbit isolated aortic rings and left atria. Both transmurally-stimulated and punctate-stimulated atria were employed to examine neurogenic and direct cardiac actions of the Ang, respectively. The peptides examined were Ang II, Ang III, and sarcosyl1-Ang II. Ang III was more potent at 33°C than at 37°C in the transmurally stimulated atria, in which the Ang III concentration–response curve was shifted roughly 10-fold to the left at 33°C in comparison to 37°C. Sarcosyl1-Ang II responses were maximal at 37°C and significantly reduced at lower temperatures in aortic rings (30°C) and in transmurally stimulated atria (30 and 33°C). Ang II actions were not significantly altered by temperature changes in the 30 to 37°C range except in transmurally stimulated atria, in which angiotensin II was more potent at 30°C than at 33°C. The results indicate that relatively small temperature alterations can profoundly affect potency ratios and maximal responses among the angiotensin peptides particularly when the angiotensin response is mediated in part by activation of sympathetic neurons, as in the transmurally stimulated atria. The data are consistent with either different mechanisms of cellular stimulation or multiple populations of receptors for the angiotensins. The greater effect of temperature alterations on angiotensin responses in the transmurally stimulated atria suggests that the peptides influence sympathetic nerves and cardiac or smooth muscle differently.

Original languageEnglish (US)
Pages (from-to)47-54
Number of pages8
JournalProceedings of the Society for Experimental Biology and Medicine
Issue number1
StatePublished - Oct 1984

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