TY - JOUR
T1 - Telomere length-associated genetic variants and the risk of thyroid cancer in survivors of childhood cancer
T2 - A report from the Childhood Cancer Survivor Study (CCSS)
AU - Gramatges, Maria M.
AU - Morton, Lindsay M.
AU - Yasui, Yutaka
AU - Arnold, Michael A.
AU - Neglia, Joseph P.
AU - Leisenring, Wendy M.
AU - Machiela, Mitchell J.
AU - Dagnall, Casey L.
AU - Chanock, Stephen J.
AU - Armstrong, Gregory T.
AU - Robison, Leslie L.
AU - Bhatia, Smita
AU - Lupo, Philip J.
N1 - Funding Information:
This work was supported by the NCI (CA194473 to M.M. Gramatges, principal investigator) and a CCSS Career Development Award to P.J. Lupo. CCSS is supported by the NCI (CA55727 to G.T. Armstrong, principal investigator), the St. Jude Children's Research Hospital Cancer Center Support (CORE) grant (CA21765 to C. Roberts, principal investigator), and the American Lebanese-Syrian Associated Charities (ALSAC). Genotyping for the study also was supported by the Intramural Research Program of the NCI, NIH.
Publisher Copyright:
© 2018 American Association for Cancer Research.
PY - 2019/2
Y1 - 2019/2
N2 - Background: Given the inverse relationship described previously between telomere content and thyroid subsequent malignant neoplasm (thyroid SMN) in survivors of childhood cancer, we investigated the relationship between known genetic determinants of leukocyte telomere length (LTL) and thyroid SMN among survivors. Methods: Leveraging data from a large, genotyped survivor cohort, the Childhood Cancer Survivor Study, we used a well-described genetic risk score method to estimate the HR for thyroid SMN among 5,324 genotyped survivors. Results: We identified 118 survivors with thyroid SMN and 5,206 without thyroid SMN. No association between genetically estimated LTL and risk for thyroid SMN was identified. Conclusions: Our results suggest that variation in common SNPs influencing LTL is not strongly associated with risk for thyroid SMN in survivors of childhood cancer. Impact: The previously observed inverse relationship between LTL and thyroid SMN risk in survivors of childhood cancer may be related to alternative molecular mechanisms and warrants further study.
AB - Background: Given the inverse relationship described previously between telomere content and thyroid subsequent malignant neoplasm (thyroid SMN) in survivors of childhood cancer, we investigated the relationship between known genetic determinants of leukocyte telomere length (LTL) and thyroid SMN among survivors. Methods: Leveraging data from a large, genotyped survivor cohort, the Childhood Cancer Survivor Study, we used a well-described genetic risk score method to estimate the HR for thyroid SMN among 5,324 genotyped survivors. Results: We identified 118 survivors with thyroid SMN and 5,206 without thyroid SMN. No association between genetically estimated LTL and risk for thyroid SMN was identified. Conclusions: Our results suggest that variation in common SNPs influencing LTL is not strongly associated with risk for thyroid SMN in survivors of childhood cancer. Impact: The previously observed inverse relationship between LTL and thyroid SMN risk in survivors of childhood cancer may be related to alternative molecular mechanisms and warrants further study.
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U2 - 10.1158/1055-9965.EPI-18-0972
DO - 10.1158/1055-9965.EPI-18-0972
M3 - Article
C2 - 30377209
AN - SCOPUS:85061051761
SN - 1055-9965
VL - 28
SP - 417
EP - 419
JO - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
IS - 2
ER -
