Abstract
In this report, we demonstrate the down-regulation of telomerase activity and c-Myc and Bcl-2 expression during 9-nitrocamptothecin (9NC)-induced regression of human DU145 prostate tumors grown as xenografts in immunodeficient mice. These changes were not observed in tumors generated by DU145-derived cells resistant to 9NC. We suggest that telomerase activity, c-Myc and Bcl-2 can collectively serve as molecular diagnostic indicators of the effectiveness of 9NC during treatment of human prostate tumors.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2885-2889 |
| Number of pages | 5 |
| Journal | Anticancer Research |
| Volume | 20 |
| Issue number | 5 |
| State | Published - 2000 |
Keywords
- 9-Nitrocamptothecin
- Myc
- Prostate cancer
- Telomerase
