Tegumental expression in larval and adult stages of a major schistosome structural glycoprotein

W S Aronstein, A P Norden, M Strand

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


A monoclonal antibody has been used to identify and characterize an antigenic tegumental surface membrane glycoprotein of Schistosoma mansoni. Direct binding of 125I-labeled monoclonal antibody showed that this glycoprotein was present in eggs, cercariae, and worms of both sexes. The glycoprotein had an apparent molecular weight of 180,000. Indirect and direct immunofluorescent microscopy showed that this antigen was located on the interlinked tegumental folds of both larval and adult parasites. These findings are discussed in relation to parasite development and the mechanism by which schistosomes evade the host's immune defenses.

Original languageEnglish (US)
Pages (from-to)334-42
Number of pages9
JournalThe American journal of tropical medicine and hygiene
Issue number2
StatePublished - Mar 1983


  • Antibodies, Monoclonal/immunology
  • Antigens/immunology
  • Autoradiography
  • Female
  • Glycoproteins/immunology
  • Male
  • Membrane Proteins/metabolism
  • Microscopy, Fluorescence
  • Molecular Weight
  • Schistosoma mansoni/metabolism

PubMed: MeSH publication types

  • Journal Article
  • Research Support, U.S. Gov't, P.H.S.


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