Technetium-99m pyrophosphate in diagnosis of acute cardiac rejection in the rat with effect of cyclosporine: Concise communication

C. G.A. McGregor, R. Hatz, S. Aziz

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Tc-99m pyrophosphate (PPi) uptake has been measured in a rat model of heterotopic heart transplant at 5 days after transplantation. Comparison of tracer uptake, as a ratio between the heterotopic transplanted heart and the recipient's native heart, was made in four groups of animals. Group 1, with transplants between animals of isogeneic strain showed a lower ratio, significantly different from the ratio in Group 2 in which transplants were between nonisogeneic animals. The ratio of uptake after transplantation between nonisogeneic animals treated with 10 mg/kg-day of cyclosporine (Group 3), was not significantly different from Group 1. In contrast, the ratio of uptake between nonisogeneic animals treated with sub-therapeutic doses of cyclosporine (Group 4), was not significantly different from Group 2. In groups 1, 2, and 3 there was a correlation between the histology of the transplanted hearts, graded 1 to 5 according to the severity of rejection, compared with the uptake of Tc-99m PPi. This agent can therefore be used to diagnose cardiac rejection in a rat model, and the results correlate well with the severity of rejection as assessed histologically.

Original languageEnglish (US)
Pages (from-to)870-873
Number of pages4
JournalJournal of Nuclear Medicine
Volume25
Issue number8
StatePublished - Jan 1 1984
Externally publishedYes

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