Tea beverage in chemoprevention and chemotherapy of prostate cancer

Imtiaz A. Siddiqui, Mohammad Saleem, Vaqar M. Adhami, Mohammad Asim, Hasan Mukhtar

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations

Abstract

Prostate cancer (PCa) is the most frequently diagnosed malignancy and the second leading cause of cancer-related deaths in American males with similar trends in many western countries. The existing treatment approaches and surgical intervention have not been able to effectively cope with this dreaded disease. For these reasons, it is necessary to intensify our efforts for a better understanding of the disease process and for the development of novel approaches for its prevention and treatment. Based on considerable evidence from in vivo and in vitro data and epidemiological studies, in recent years the beverage tea has gained considerable attention for reducing the risk of several cancers. Much of the cancer preventive effects of tea, especially green tea appear to be mediated by the polyphenols present therein. Geographical evidence suggests that the incidence and occurrence of PCa is lower in populations that consume tea regularly. This evidence suggests that tea polyphenols could be extrapolated to optimize their chemopreventive properties against PCa. PCa represents an excellent candidate disease for chemoprevention because it is typically diagnosed in men over 50 years of age and therefore, even a modest delay in neoplastic development achieved through pharmacological or nutritional intervention could result in a substantial reduction in the incidence of clinically detectable disease. In this review we address the issue of possible use of tea, especially green tea, for the prevention as well as treatment of PCa.

Original languageEnglish (US)
Pages (from-to)1392-1408
Number of pages17
JournalActa Pharmacologica Sinica
Volume28
Issue number9
DOIs
StatePublished - Sep 2007
Externally publishedYes

Keywords

  • (-)epicatechin
  • (-)epigallocatechin-3-gallate
  • Androgen receptor
  • Apoptosis
  • Clinical studies
  • Epidemiology
  • Green tea
  • PSA
  • Tumor xenograft

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