TCF7L2 single nucleotide polymorphisms, cardiovascular disease and all-cause mortality: The Atherosclerosis Risk in Communities (ARIC) study

S. J. Bielinski, J. S. Pankow, A. R. Folsom, K. E. North, E. Boerwinkle

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Aims/hypothesis: We hypothesised that TCF7L2 single nucleotide polymorphisms (SNPs) are associated with cardiovascular disease (CVD) and that the associations differ in diabetic and non-diabetic persons. Methods: Our analysis included black and white participants from the Atherosclerosis Risk in Communities study who were free of prevalent CVD at baseline and had been genotyped for rs7903146, rs12255372, rs7901695, rs11196205 and rs7895340 (n=13,369). Cox proportional hazard regression was used to estimate the associations between polymorphisms and incident events; logistic and linear regression were used for associations with baseline risk factor levels. Results: TCF7L2 SNPs were not significantly associated with incident coronary heart disease, ischaemic stroke, CVD, prevalent peripheral artery disease (PAD) or all-cause mortality in the full cohort or when stratified by race. Conclusions/interpretation: In the whole cohort, TCF7L2 SNPs were not associated with incident CVD, all-cause mortality or prevalent PAD. This result suggests that the increased health risk associated with rs7903146 genotype is specific to diabetes.

Original languageEnglish (US)
Pages (from-to)968-970
Number of pages3
JournalDiabetologia
Volume51
Issue number6
DOIs
StatePublished - Jun 2008

Bibliographical note

Funding Information:
Study is a collaborative study supported by National Heart, Lung, and Blood Institute contracts N01-HC-55015, N01-HC-55016, N01-HC-55018, N01-HC-55019, N01-HC-55020, N01-HC-55021 and N01-HC-55022. The authors thank the staff and participants of the ARIC study for their important contributions.

Keywords

  • All-cause mortality
  • Cardiovascular disease
  • Coronary heart disease
  • Diabetes
  • Peripheral artery disease
  • Stroke
  • TCF7L2
  • Transcription factor 7-like 2

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