TCAB1: Driving telomerase to Cajal bodies

Andrew S. Venteicher, Steven E. Artandi

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

Telomerase supports the proliferation of progenitor cells and tumor cells by adding telomere repeats to chromosome ends. The low abundance and restricted expression pattern of telomerase have limited our knowledge of this important enzyme. A new telomerase protein, TCAB1, sheds light on the pathway that governs telomerase holoenzyme assembly and function in vivo. TCAB1 is a component of active telomerase and is required for the telomerase holoenzyme to accumulate in Cajal bodies and to elongate telomeres. These findings provide important new insights into how telomerase functions in cancer and in stem cell biology.

Original languageEnglish (US)
Pages (from-to)1329-1331
Number of pages3
JournalCell Cycle
Volume8
Issue number9
DOIs
StatePublished - May 1 2009

Keywords

  • Cajal body
  • Cancer
  • Stem cells
  • TCAB1
  • Telomerase
  • Telomere
  • WD repeat

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