Taxol Photoaffinity Label: 7-(p-Azidobenzoyl)taxol Synthesis and Biological Evaluation

Gunda I. George; Geraldine C.B. Harriman; Richard H. Himes; Magdalena R. Mejillano

doi:10.1016/S0960-894X(00)80402-3

Taxol Photoaffinity Label: 7-(p-Azidobenzoyl)taxol Synthesis and Biological Evaluation

Gunda I. George
, Geraldine C.B. Harriman
, Richard H. Himes
, Magdalena R. Mejillano

Medicinal Chemistry

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

An efficient semi-synthetic approach utilizing the appropriately functionalized (3R,4S)-3-hydroxy-4-phenyl-2-azetidinone (4) and 7-(p-azidobenzoyl)baccatin III (3) is described which leads to the targeted biologically active taxol photoaffinity label 6.

Original language	English (US)
Pages (from-to)	735-738
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	2
Issue number	7
DOIs	https://doi.org/10.1016/S0960-894X(00)80402-3
State	Published - Jul 1992

Keywords

Taxol
microtubule assembly
photoaffinity label.
synthesis
β-lactams

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10.1016/S0960-894X(00)80402-3

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title = "Taxol Photoaffinity Label: 7-(p-Azidobenzoyl)taxol Synthesis and Biological Evaluation",

abstract = "An efficient semi-synthetic approach utilizing the appropriately functionalized (3R,4S)-3-hydroxy-4-phenyl-2-azetidinone (4) and 7-(p-azidobenzoyl)baccatin III (3) is described which leads to the targeted biologically active taxol photoaffinity label 6.",

keywords = "Taxol, microtubule assembly, photoaffinity label., synthesis, β-lactams",

author = "George, \{Gunda I.\} and Harriman, \{Geraldine C.B.\} and Himes, \{Richard H.\} and Mejillano, \{Magdalena R.\}",

year = "1992",

month = jul,

doi = "10.1016/S0960-894X(00)80402-3",

language = "English (US)",

volume = "2",

pages = "735--738",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Ltd",

number = "7",

}

TY - JOUR

T1 - Taxol Photoaffinity Label

T2 - 7-(p-Azidobenzoyl)taxol Synthesis and Biological Evaluation

AU - George, Gunda I.

AU - Harriman, Geraldine C.B.

AU - Himes, Richard H.

AU - Mejillano, Magdalena R.

PY - 1992/7

Y1 - 1992/7

N2 - An efficient semi-synthetic approach utilizing the appropriately functionalized (3R,4S)-3-hydroxy-4-phenyl-2-azetidinone (4) and 7-(p-azidobenzoyl)baccatin III (3) is described which leads to the targeted biologically active taxol photoaffinity label 6.

AB - An efficient semi-synthetic approach utilizing the appropriately functionalized (3R,4S)-3-hydroxy-4-phenyl-2-azetidinone (4) and 7-(p-azidobenzoyl)baccatin III (3) is described which leads to the targeted biologically active taxol photoaffinity label 6.

KW - Taxol

KW - microtubule assembly

KW - photoaffinity label.

KW - synthesis

KW - β-lactams

UR - https://www.scopus.com/pages/publications/0026661942

UR - https://www.scopus.com/pages/publications/0026661942#tab=citedBy

U2 - 10.1016/S0960-894X(00)80402-3

DO - 10.1016/S0960-894X(00)80402-3

M3 - Article

AN - SCOPUS:0026661942

SN - 0960-894X

VL - 2

SP - 735

EP - 738

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 7

ER -

Taxol Photoaffinity Label: 7-(p-Azidobenzoyl)taxol Synthesis and Biological Evaluation

Abstract

Keywords

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