Taste in chimpanzees. III: Labeled-line coding in sweet taste

G. Hellekant, Y. Ninomiya, V. Danilova

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

In peripheral taste the coding mechanism remains an enigma. Among coding theories the 'across-fiber pattern' argues that activity across fibers codes for taste, whereas the 'labeled line' claims that activity in a particular set of fibers underlies a taste quality. We showed previously that chimpanzee chorda tympani taste fibers grouped according to human taste qualities into an S-cluster, responding predominantly to sweet stimuli, a Q-cluster, sensitive to bitter tastants, and an N-cluster, stimulated by salts. The analysis showed that information in the S-line suffices to distinguish stimuli of one taste quality from the others. However, one condition for the labeled line remained: that blockage of activity in a particular line must cause blockage of one taste quality, but of no other, or its onset give rise to the sensation of a taste quality. Here we studied this requirement with gymnemic acids and miraculin. In humans and chimpanzees, gymnemic acids suppress the sweet taste of all sweeteners whereas miraculin adds a sweet taste quality to sour stimuli. Gymnemic acids also abolish miraculin-induced sweet taste. We found that gymnemic acids practically abolished the response to every sweetener in the chimpanzee S-cluster. Equally important, they had no effect on the responses of the Q- and N-clusters. After miraculin, the S-cluster fibers responded to acids as well as to sweeteners, although they had not responded to acids before miraculin. Gymnemic acids abolished this miraculin-induced response to acids and responses to sweeteners in the S-fibers. These results link the sweet taste quality to activity in fibers of the S-cluster. Thus the S-cluster fibers satisfy the definition of the labeled-line theory: 'that activity in a particular fiber type represents a specific taste quality.' Copyright (C) 1998 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)191-200
Number of pages10
JournalPhysiology and Behavior
Volume65
Issue number2
DOIs
StatePublished - Nov 15 1998

Keywords

  • Across-fiber pattern
  • Chimpanzee
  • Chorda tympani
  • Coding
  • Gymnemic acids
  • Labeled line
  • Miraculin
  • Pan troglodytes
  • Taste

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