Task-Related modulations of BOLD low-frequency fluctuations within the default mode Network

Silvia Tommasin, Daniele Mascali, Tommaso Gili, Ibrahim Eid Assan, Marta Moraschi, Michela Fratini, Richard G. Wise, Emiliano Macaluso, Silvia Mangia, Federico Giove

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Spontaneous low-frequency Blood-Oxygenation Level-Dependent (BOLD) signals acquired during resting state are characterized by spatial patterns of synchronous fluctuations, ultimately leading to the identification of robust brain networks. The resting-state brain networks, including the Default Mode Network (DMN), are demonstrated to persist during sustained task execution, but the exact features of task-related changes of network properties are still not well characterized. In this work we sought to examine in a group of 20 healthy volunteers (age 33 ± 6 years, 8 F/12 M) the relationship between changes of spectral and spatiotemporal features of one prominent resting-state network, namely the DMN, during the continuous execution of a working memory n-back task. We found that task execution impacted on both functional connectivity and amplitude of BOLD fluctuations within large parts of the DMN, but these changes correlated between each other only in a small area of the posterior cingulate. We conclude that combined analysis of multiple parameters related to connectivity, and their changes during the transition from resting state to continuous task execution, can contribute to a better understanding of how brain networks rearrange themselves in response to a task.

Original languageEnglish (US)
Article number31
JournalFrontiers in Physics
Volume5
Issue numberJUL
DOIs
StatePublished - Jul 25 2017

Fingerprint

Oxygenation
oxygenation
blood
Blood
Low Frequency
Brain
Modulation
Fluctuations
low frequencies
modulation
Dependent
Gyrus Cinguli
brain
Short-Term Memory
Healthy Volunteers
Data storage equipment
Connectivity
Working Memory
Spatial Pattern

Keywords

  • DMN
  • Functional connectivity
  • Low frequency BOLD fluctuations
  • Working memory
  • fALFF

Cite this

Tommasin, S., Mascali, D., Gili, T., Assan, I. E., Moraschi, M., Fratini, M., ... Giove, F. (2017). Task-Related modulations of BOLD low-frequency fluctuations within the default mode Network. Frontiers in Physics, 5(JUL), [31]. https://doi.org/10.3389/fphy.2017.00031

Task-Related modulations of BOLD low-frequency fluctuations within the default mode Network. / Tommasin, Silvia; Mascali, Daniele; Gili, Tommaso; Assan, Ibrahim Eid; Moraschi, Marta; Fratini, Michela; Wise, Richard G.; Macaluso, Emiliano; Mangia, Silvia; Giove, Federico.

In: Frontiers in Physics, Vol. 5, No. JUL, 31, 25.07.2017.

Research output: Contribution to journalArticle

Tommasin, S, Mascali, D, Gili, T, Assan, IE, Moraschi, M, Fratini, M, Wise, RG, Macaluso, E, Mangia, S & Giove, F 2017, 'Task-Related modulations of BOLD low-frequency fluctuations within the default mode Network', Frontiers in Physics, vol. 5, no. JUL, 31. https://doi.org/10.3389/fphy.2017.00031
Tommasin, Silvia ; Mascali, Daniele ; Gili, Tommaso ; Assan, Ibrahim Eid ; Moraschi, Marta ; Fratini, Michela ; Wise, Richard G. ; Macaluso, Emiliano ; Mangia, Silvia ; Giove, Federico. / Task-Related modulations of BOLD low-frequency fluctuations within the default mode Network. In: Frontiers in Physics. 2017 ; Vol. 5, No. JUL.
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