Task force 4. Efficacy of risk factor management

J. S. Forrester, C. N. Bairey, T. L. Bush, J. N. Cohn, D. B. Hunninghake, S. Parthasarathy, H. R. Superko

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

Observational and clinical trial data provide a substantial information base upon which current and future recommendations can be made for preventive therapy of coronary artery disease. Based on these data, it is possible to stratify potential therapies into four levels of anticipated effectiveness: 1) Interventions proven to alter risk are those directed at diet, LDL cholesterol, hypertension, smoking and platelet adhesion. 2) Interventions that are likely to alter risk are those directed at diabetes; physical inactivity; HDL cholesterol; triglycerides and small, dense LDL; obesity; and estrogen replacement. 3) Interventions that might alter risk are those directed at homocysteine, Lp(a) and oxidative stress. 4) Risk factors that cannot be modified include age, gender and family history. As the contribution of genetically regulated risk factors are further defined, it seems likely that prevention of coronary artery disease and its complications will become progressively individualized and increasingly effective.

Original languageEnglish (US)
Pages (from-to)991-1006
Number of pages16
JournalJournal of the American College of Cardiology
Volume27
Issue number5
DOIs
StatePublished - Apr 1996

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    Forrester, J. S., Bairey, C. N., Bush, T. L., Cohn, J. N., Hunninghake, D. B., Parthasarathy, S., & Superko, H. R. (1996). Task force 4. Efficacy of risk factor management. Journal of the American College of Cardiology, 27(5), 991-1006. https://doi.org/10.1016/0735-1097(96)87732-1