Tartrolon E, a secondary metabolite of a marine symbiotic bacterium, is a potent inhibitor of asexual and sexual Plasmodium falciparum

Laura Chery-Karschney; Rapatbhorn Patrapuvich; Devaraja Gouda Mudeppa; Sreekanth Kokkonda; Rimi Chakrabarti; Patchara Sriwichai; Roberta M. O'Connor; Pradipsinh K. Rathod; John White

doi:10.1128/aac.00684-23

Tartrolon E, a secondary metabolite of a marine symbiotic bacterium, is a potent inhibitor of asexual and sexual Plasmodium falciparum

Laura Chery-Karschney
, Rapatbhorn Patrapuvich
, Devaraja Gouda Mudeppa
, Sreekanth Kokkonda
, Rimi Chakrabarti
, Patchara Sriwichai
, Roberta M. O'Connor
, Pradipsinh K. Rathod
, John White

Veterinary and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Due to the spread of resistance to front-line artemisinin derivatives worldwide, there is a need for new antimalarials. Tartrolon E (TrtE), a secondary metabolite of a symbiotic bacterium of marine bivalve mollusks, is a promising antimalarial because it inhibits the growth of sexual and asexual blood stages of Plasmodium falciparum at sub-nanomolar levels. The potency of TrtE warrants further investigation into its mechanism of action, cytotoxicity, and ease with which parasites may evolve resistance to it.

Original language	English (US)
Journal	Antimicrobial agents and chemotherapy
Volume	68
Issue number	2
DOIs	https://doi.org/10.1128/aac.00684-23
State	Published - Feb 2024

Bibliographical note

Publisher Copyright:
© 2024 American Society for Microbiology. All rights reserved.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

gametocidal
malaria
marine natural product
shipworm symbiont

PubMed: MeSH publication types

Journal Article
Research Support, N.I.H., Extramural

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10.1128/aac.00684-23

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Chery-Karschney, L., Patrapuvich, R., Mudeppa, D. G., Kokkonda, S., Chakrabarti, R., Sriwichai, P., O'Connor, R. M., Rathod, P. K., & White, J. (2024). Tartrolon E, a secondary metabolite of a marine symbiotic bacterium, is a potent inhibitor of asexual and sexual Plasmodium falciparum. Antimicrobial agents and chemotherapy, 68(2). https://doi.org/10.1128/aac.00684-23

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abstract = "Due to the spread of resistance to front-line artemisinin derivatives worldwide, there is a need for new antimalarials. Tartrolon E (TrtE), a secondary metabolite of a symbiotic bacterium of marine bivalve mollusks, is a promising antimalarial because it inhibits the growth of sexual and asexual blood stages of Plasmodium falciparum at sub-nanomolar levels. The potency of TrtE warrants further investigation into its mechanism of action, cytotoxicity, and ease with which parasites may evolve resistance to it.",

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author = "Laura Chery-Karschney and Rapatbhorn Patrapuvich and Mudeppa, \{Devaraja Gouda\} and Sreekanth Kokkonda and Rimi Chakrabarti and Patchara Sriwichai and O'Connor, \{Roberta M.\} and Rathod, \{Pradipsinh K.\} and John White",

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doi = "10.1128/aac.00684-23",

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T1 - Tartrolon E, a secondary metabolite of a marine symbiotic bacterium, is a potent inhibitor of asexual and sexual Plasmodium falciparum

AU - Chery-Karschney, Laura

AU - Patrapuvich, Rapatbhorn

AU - Mudeppa, Devaraja Gouda

AU - Kokkonda, Sreekanth

AU - Chakrabarti, Rimi

AU - Sriwichai, Patchara

AU - O'Connor, Roberta M.

AU - Rathod, Pradipsinh K.

AU - White, John

PY - 2024/2

Y1 - 2024/2

N2 - Due to the spread of resistance to front-line artemisinin derivatives worldwide, there is a need for new antimalarials. Tartrolon E (TrtE), a secondary metabolite of a symbiotic bacterium of marine bivalve mollusks, is a promising antimalarial because it inhibits the growth of sexual and asexual blood stages of Plasmodium falciparum at sub-nanomolar levels. The potency of TrtE warrants further investigation into its mechanism of action, cytotoxicity, and ease with which parasites may evolve resistance to it.

AB - Due to the spread of resistance to front-line artemisinin derivatives worldwide, there is a need for new antimalarials. Tartrolon E (TrtE), a secondary metabolite of a symbiotic bacterium of marine bivalve mollusks, is a promising antimalarial because it inhibits the growth of sexual and asexual blood stages of Plasmodium falciparum at sub-nanomolar levels. The potency of TrtE warrants further investigation into its mechanism of action, cytotoxicity, and ease with which parasites may evolve resistance to it.

KW - gametocidal

KW - malaria

KW - marine natural product

KW - shipworm symbiont

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UR - https://www.scopus.com/pages/publications/85184521084#tab=citedBy

U2 - 10.1128/aac.00684-23

DO - 10.1128/aac.00684-23

M3 - Article

C2 - 38193705

AN - SCOPUS:85184521084

SN - 0066-4804

VL - 68

JO - Antimicrobial agents and chemotherapy

JF - Antimicrobial agents and chemotherapy

IS - 2

ER -

Tartrolon E, a secondary metabolite of a marine symbiotic bacterium, is a potent inhibitor of asexual and sexual Plasmodium falciparum

Abstract

Bibliographical note

UN SDGs

Keywords

PubMed: MeSH publication types

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