Targeting the ensemble of heterogeneous tau oligomers in cells: A novel small molecule screening platform for tauopathies

Keyphrases

• Tauopathy 100%
• Tau Oligomers 100%
• Screening Platform 100%
• Biomolecule Detection 100%
• Tool Compound 50%
• Biosensor Technology 25%
• MK886 25%
• Single-molecule Fluorescence Resonance Energy Transfer (smFRET) 25%
• High-resolution 12%
• Structural Change 12%
• Alzheimer's Disease 12%
• Atomic Scale 12%
• Disease-modifying Therapy 12%
• Cytotoxicity 12%
• Pathologic 12%
• Molecular Chaperone 12%
• Post-translational Modification 12%
• New Therapeutics 12%
• Biomarker Profile 12%
• Cross-reactivity 12%
• Binding Region 12%
• Microtubule Binding 12%
• Structural Features 12%
• Microtubule-associated Protein 12%
• Fundamental Challenges 12%
• Toxic Species 12%
• Proline-rich 12%
• Intrinsically Disordered Proteins 12%
• Objective Understanding 12%
• Protein tau 12%
• Oligomer Structure 12%
• Oligomer Toxicity 12%
• Familial Alzheimer's 12%
• τ-induced 12%
• Tau Assembly 12%
• Structural Fingerprint 12%
• Novel Disease 12%
• Therapeutic Development 12%
• Major Challenges 12%
• Alzheime's Disease 12%
• Neurodegenerative Disorders 12%
• Proof of Concept Study 12%

Biochemistry, Genetics and Molecular Biology

• Small Molecule 100%
• Tau 100%
• Conformation 29%
• Fluorescence Resonance Energy Transfer 11%
• Isoform 5%
• Binding Protein 5%
• Posttranslational Modification 5%
• Intrinsically Disordered Protein 5%
• Cross Reaction 5%
• Cytotoxicity 5%
• Gene Linkage 5%
• Proline 5%
• Chaperone 5%