Targeting protein-protein interactions by small molecules

Chunquan Sheng, Gunda I. Georg

Research output: Book/ReportBook

1 Scopus citations


This book comprehensively reviews the state-of-the-art strategies developed for protein-protein interaction (PPI) inhibitors, and highlights the success stories in new drug discovery and development. Consisting of two parts with twelve chapters, it demonstrates the design strategies and case studies of small molecule PPI inhibitors. The first part discusses various discovery strategies for small molecule PPI inhibitors, such as high throughput screening, hot spot-based design, computational approaches, and fragment-based design. The second part presents recent advances in small molecule inhibitors, focusing on clinical candidates and new PPI targets. This book has broad appeal and is of significant interest to the pharmaceutical science and medicinal chemistry communities.

Original languageEnglish (US)
PublisherSpringer Singapore
Number of pages329
ISBN (Electronic)9789811307737
ISBN (Print)9789811307720
StatePublished - Jun 26 2018

Bibliographical note

Publisher Copyright:
© Springer Nature Singapore Pte Ltd. 2018. All rights reserved.


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