Targeting platelet-derived CXCL12 impedes arterial thrombosis

Keyphrases

• Platelet-derived Growth factor-BB (PDGF-BB) 100%
• Arterial Thrombosis 100%
• Chemokine Ligand 12 (CXCL12) 100%
• Platelet Aggregation 40%
• C-X-C Chemokine Receptor Type 4 (CXCR4) 40%
• Platelets 30%
• CCL5 20%
• Bruton's Tyrosine Kinase 20%
• Therapeutic Approaches 10%
• Mediating Effect 10%
• Integrin 10%
• Molecular Mechanism 10%
• Aspirin 10%
• Collagen 10%
• Antiplatelet Therapy 10%
• Atherothrombosis 10%
• Potential Therapeutics 10%
• Kinase Activation 10%
• Signaling Cascades 10%
• Neointimal Lesion 10%
• Bleeding Time 10%
• Bleeding Events 10%
• Target-based Approach 10%
• Therapeutic Implications 10%
• Granule Release 10%
• Human Plaque 10%
• Arterial Flow 10%
• Tail Bleeding Time 10%
• Activated Platelets 10%
• Collagen-induced 10%
• Platelet Granules 10%
• Thrombus Stability 10%
• Carotid Artery Injury 10%
• Thrombus Growth 10%
• Chemokine CXCL12 10%
• P2Y12 Inhibition 10%
• Ischemic Events 10%
• Derived Peptide 10%
• Lesion Formation 10%
• Static Flow 10%
• Flow Conditions 10%
• Aggregation-induced 10%

Biochemistry, Genetics and Molecular Biology

• Platelet 100%
• Thrombocyte Aggregation 80%
• CXCR4 80%
• Peptide 60%
• CCL5 40%
• Bleeding Time 40%
• Bruton Tyrosine Kinase 40%
• Integrin 20%
• Homogenate 20%
• Artery Blood Flow 20%
• Thrombocyte Activation 20%
• P2Y12 20%
• Stromal Cell-Derived Factor 1 20%
• Deficiency 20%
• Molecular Mechanism 20%

Pharmacology, Toxicology and Pharmaceutical Science

• Artery Thrombosis 100%
• Peptide 60%
• Bleeding 40%
• Bruton Tyrosine Kinase 40%
• Thrombus 20%
• Antiplatelet 20%
• Acetylsalicylic Acid 20%
• Integrin 20%
• Chemokine Receptor CXCR4 20%
• Stromal Cell Derived Factor 1 20%
• Thrombosis 20%
• Carotid Artery Injury 20%