Targeting KIR blockade in multiple myeloma: Trouble in checkpoint paradise?

Martin Felices; Jeffrey S. Miller

doi:10.1158/1078-0432.CCR-16-1582

Targeting KIR blockade in multiple myeloma: Trouble in checkpoint paradise?

Martin Felices, Jeffrey S. Miller

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Findings within the current issue indicate that treatment with IPH2101 when used as a monotherapy in smoldering multiple myeloma, meant to enhance natural killer (NK) cell function through inhibitory KIR blockade, results in a surprising reduction of NK-cell function mediated through monocyte trogocytosis. The significance of these findings is discussed.

Original language	English (US)
Pages (from-to)	5161-5163
Number of pages	3
Journal	Clinical Cancer Research
Volume	22
Issue number	21
DOIs	https://doi.org/10.1158/1078-0432.CCR-16-1582
State	Published - Nov 1 2016

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Publisher Copyright:
©2016 AACR.

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10.1158/1078-0432.CCR-16-1582

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title = "Targeting KIR blockade in multiple myeloma: Trouble in checkpoint paradise?",

abstract = "Findings within the current issue indicate that treatment with IPH2101 when used as a monotherapy in smoldering multiple myeloma, meant to enhance natural killer (NK) cell function through inhibitory KIR blockade, results in a surprising reduction of NK-cell function mediated through monocyte trogocytosis. The significance of these findings is discussed.",

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AB - Findings within the current issue indicate that treatment with IPH2101 when used as a monotherapy in smoldering multiple myeloma, meant to enhance natural killer (NK) cell function through inhibitory KIR blockade, results in a surprising reduction of NK-cell function mediated through monocyte trogocytosis. The significance of these findings is discussed.

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Targeting KIR blockade in multiple myeloma: Trouble in checkpoint paradise?

Abstract

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