Targeting IRES-mediated p53 synthesis for cancer diagnosis and therapeutics

Bai Ji; Benjamin R.E. Harris; Yahui Liu; Yibin Deng; Sergio Gradilone; Margot P Cleary; Jianhua Liu; DaQing Yang

doi:10.3390/ijms18010093

Targeting IRES-mediated p53 synthesis for cancer diagnosis and therapeutics

Bai Ji, Benjamin R.E. Harris, Yahui Liu, Yibin Deng, Sergio Gradilone, Margot P Cleary, Jianhua Liu, DaQing Yang

The Hormel Institute

Research output: Contribution to journal › Review article › peer-review

14 Scopus citations

Abstract

While translational regulation of p53 by the internal ribosome entry site (IRES) at its 50-untranslated region following DNA damage has been widely accepted, the detailed mechanism underlying the translational control of p53 by its IRES sequence is still poorly understood. In this review, we will focus on the latest progress in identifying novel regulatory proteins of the p53 IRES and in uncovering the functional connection between defective IRES-mediated p53 translation and tumorigenesis. We will also discuss how these findings may lead to a better understanding of the process of oncogenesis and open up new avenues for cancer diagnosis and therapeutics.

Original language	English (US)
Article number	93
Journal	International journal of molecular sciences
Volume	18
Issue number	1
DOIs	https://doi.org/10.3390/ijms18010093
State	Published - Jan 4 2017

Bibliographical note

Funding Information:
Funding for this research was provided by an Idea Award (#BC051719) from the Department of Defense, two research grants (1RO3#ES017869, and 1RO3#CA177954) from NIH, an Institutional Research Grant (#118198-IRG-58-001-52-IRG99) from American Cancer Society, and the Hormel Foundation.

Publisher Copyright:
© 2017 by the authors; licensee MDPI, Basel, Switzerland.

Keywords

DNA damage
IRES-trans acting factors (ITAFs)
Internal ribosome entry site (IRES)
P53

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/ijms18010093

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abstract = "While translational regulation of p53 by the internal ribosome entry site (IRES) at its 50-untranslated region following DNA damage has been widely accepted, the detailed mechanism underlying the translational control of p53 by its IRES sequence is still poorly understood. In this review, we will focus on the latest progress in identifying novel regulatory proteins of the p53 IRES and in uncovering the functional connection between defective IRES-mediated p53 translation and tumorigenesis. We will also discuss how these findings may lead to a better understanding of the process of oncogenesis and open up new avenues for cancer diagnosis and therapeutics.",

keywords = "DNA damage, IRES-trans acting factors (ITAFs), Internal ribosome entry site (IRES), P53",

author = "Bai Ji and Harris, {Benjamin R.E.} and Yahui Liu and Yibin Deng and Sergio Gradilone and Cleary, {Margot P} and Jianhua Liu and DaQing Yang",

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AU - Ji, Bai

AU - Harris, Benjamin R.E.

AU - Liu, Yahui

AU - Deng, Yibin

AU - Gradilone, Sergio

AU - Cleary, Margot P

AU - Liu, Jianhua

AU - Yang, DaQing

N1 - Funding Information: Funding for this research was provided by an Idea Award (#BC051719) from the Department of Defense, two research grants (1RO3#ES017869, and 1RO3#CA177954) from NIH, an Institutional Research Grant (#118198-IRG-58-001-52-IRG99) from American Cancer Society, and the Hormel Foundation. Publisher Copyright: © 2017 by the authors; licensee MDPI, Basel, Switzerland.

PY - 2017/1/4

Y1 - 2017/1/4

N2 - While translational regulation of p53 by the internal ribosome entry site (IRES) at its 50-untranslated region following DNA damage has been widely accepted, the detailed mechanism underlying the translational control of p53 by its IRES sequence is still poorly understood. In this review, we will focus on the latest progress in identifying novel regulatory proteins of the p53 IRES and in uncovering the functional connection between defective IRES-mediated p53 translation and tumorigenesis. We will also discuss how these findings may lead to a better understanding of the process of oncogenesis and open up new avenues for cancer diagnosis and therapeutics.

AB - While translational regulation of p53 by the internal ribosome entry site (IRES) at its 50-untranslated region following DNA damage has been widely accepted, the detailed mechanism underlying the translational control of p53 by its IRES sequence is still poorly understood. In this review, we will focus on the latest progress in identifying novel regulatory proteins of the p53 IRES and in uncovering the functional connection between defective IRES-mediated p53 translation and tumorigenesis. We will also discuss how these findings may lead to a better understanding of the process of oncogenesis and open up new avenues for cancer diagnosis and therapeutics.

KW - DNA damage

KW - IRES-trans acting factors (ITAFs)

KW - Internal ribosome entry site (IRES)

KW - P53

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DO - 10.3390/ijms18010093

M3 - Review article

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JF - International Journal of Molecular Sciences

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Targeting IRES-mediated p53 synthesis for cancer diagnosis and therapeutics

Abstract

Bibliographical note

Keywords

UN SDGs

Publisher link

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