Targeting human epidermal growth factor receptor 2 (HER2) in gynecologic malignancies

Britt K. Erickson, Burak Zeybek, Alessandro D. Santin, Amanda N. Fader

Research output: Contribution to journalReview article

Abstract

Purpose of reviewThe purpose of this review is to describe the role of the human epidermal growth factor receptor 2 (HER2) as a biomarker and potential target in gynecologic malignancies and to describe contemporary updates in the use of anti-HER2 treatments for these cancers.Recent findingsApproximately 25-30% of all patients with uterine serous carcinoma overexpress tumoral HER2. The anti-HER2 antibody trastuzumab represents an effective, targeted therapy with significant efficacy in the treatment of HER2-positive breast and gastric cancer. Recently, trastuzumab efficacy has also been demonstrated in a randomized controlled trial of women with advanced or recurrent uterine serous carcinoma. Additionally, trastuzumab may be effective in women with HER2-positive uterine carcinosarcoma. The role of anti-HER2 therapy is unclear in women with other gynecologic malignancies but is being evaluated.SummaryHER2 amplification/overexpression is an effective therapeutic target in select gynecologic malignancies, and especially in the rare endometrial cancer subtype, uterine serous carcinoma. As anti-HER2-targeted therapies become increasingly available, more treatment options may become available for women with HER2-positive disease.

Original languageEnglish (US)
Pages (from-to)57-64
Number of pages8
JournalCurrent Opinion in Obstetrics and Gynecology
Volume32
Issue number1
DOIs
StatePublished - Feb 1 2020

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Keywords

  • biomarker
  • human epidermal growth factor receptor 2
  • ovarian cancer
  • uterine serous carcinoma

PubMed: MeSH publication types

  • Journal Article

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