Targeting hexokinase 2 in castration-resistant prostate cancer

Yibin Deng; Junxuan Lu

doi:10.4161/23723556.2014.974465

Targeting hexokinase 2 in castration-resistant prostate cancer

Yibin Deng
, Junxuan Lu

Research output: Contribution to journal › Comment/debate › peer-review

22 Scopus citations

Abstract

Aerobic glycolysis, known as the Warburg effect, is one of the hallmarks of cancer cells. We recently reported that the hexokinase 2 (HK2)-mediated Warburg effect is required for castration-resistant prostate cancer that is driven by Pten/p53 deficiency, suggesting that HK2 might be a therapeutic target for prostate cancer patients carrying PTEN and p53 mutations.

Original language	English (US)
Article number	e974465
Journal	Molecular and Cellular Oncology
Volume	2
Issue number	3
DOIs	https://doi.org/10.4161/23723556.2014.974465
State	Published - Jul 3 2015

Bibliographical note

Funding Information:
This work was supported, in part, by grants from the US National Cancer Institute (R01 CA160333, YD; R21 CA155522, YD and JL; R01 CA172169, JL and YD), The University of Minnesota Grant-in Aid (YD) and start-up funds from The Hormel Foundation (YD).

Publisher Copyright:
© 2015, © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC. © 2015, © Yibin Deng and Junxuan Lu.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

CRPC
HK2
PTEN
Warburg effect
p53

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10.4161/23723556.2014.974465

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title = "Targeting hexokinase 2 in castration-resistant prostate cancer",

abstract = "Aerobic glycolysis, known as the Warburg effect, is one of the hallmarks of cancer cells. We recently reported that the hexokinase 2 (HK2)-mediated Warburg effect is required for castration-resistant prostate cancer that is driven by Pten/p53 deficiency, suggesting that HK2 might be a therapeutic target for prostate cancer patients carrying PTEN and p53 mutations.",

keywords = "CRPC, HK2, PTEN, Warburg effect, p53",

author = "Yibin Deng and Junxuan Lu",

note = "Funding Information: This work was supported, in part, by grants from the US National Cancer Institute (R01 CA160333, YD; R21 CA155522, YD and JL; R01 CA172169, JL and YD), The University of Minnesota Grant-in Aid (YD) and start-up funds from The Hormel Foundation (YD). Publisher Copyright: {\textcopyright} 2015, {\textcopyright} 2015 The Author(s). Published with license by Taylor \& Francis Group, LLC. {\textcopyright} 2015, {\textcopyright} Yibin Deng and Junxuan Lu.",

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AU - Deng, Yibin

AU - Lu, Junxuan

N1 - Funding Information: This work was supported, in part, by grants from the US National Cancer Institute (R01 CA160333, YD; R21 CA155522, YD and JL; R01 CA172169, JL and YD), The University of Minnesota Grant-in Aid (YD) and start-up funds from The Hormel Foundation (YD). Publisher Copyright: © 2015, © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC. © 2015, © Yibin Deng and Junxuan Lu.

PY - 2015/7/3

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N2 - Aerobic glycolysis, known as the Warburg effect, is one of the hallmarks of cancer cells. We recently reported that the hexokinase 2 (HK2)-mediated Warburg effect is required for castration-resistant prostate cancer that is driven by Pten/p53 deficiency, suggesting that HK2 might be a therapeutic target for prostate cancer patients carrying PTEN and p53 mutations.

AB - Aerobic glycolysis, known as the Warburg effect, is one of the hallmarks of cancer cells. We recently reported that the hexokinase 2 (HK2)-mediated Warburg effect is required for castration-resistant prostate cancer that is driven by Pten/p53 deficiency, suggesting that HK2 might be a therapeutic target for prostate cancer patients carrying PTEN and p53 mutations.

KW - CRPC

KW - HK2

KW - PTEN

KW - Warburg effect

KW - p53

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DO - 10.4161/23723556.2014.974465

M3 - Comment/debate

AN - SCOPUS:85025676935

SN - 2372-3556

VL - 2

JO - Molecular and Cellular Oncology

JF - Molecular and Cellular Oncology

IS - 3

M1 - e974465

ER -

Targeting hexokinase 2 in castration-resistant prostate cancer

Abstract

Bibliographical note

UN SDGs

Keywords

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