Targeting hexokinase 2 in castration-resistant prostate cancer

Yibin Deng, Junxuan Lu

Research output: Contribution to journalComment/debatepeer-review

17 Scopus citations


Aerobic glycolysis, known as the Warburg effect, is one of the hallmarks of cancer cells. We recently reported that the hexokinase 2 (HK2)-mediated Warburg effect is required for castration-resistant prostate cancer that is driven by Pten/p53 deficiency, suggesting that HK2 might be a therapeutic target for prostate cancer patients carrying PTEN and p53 mutations.

Original languageEnglish (US)
Article numbere974465
JournalMolecular and Cellular Oncology
Issue number3
StatePublished - Jul 3 2015

Bibliographical note

Funding Information:
This work was supported, in part, by grants from the US National Cancer Institute (R01 CA160333, YD; R21 CA155522, YD and JL; R01 CA172169, JL and YD), The University of Minnesota Grant-in Aid (YD) and start-up funds from The Hormel Foundation (YD).

Publisher Copyright:
© 2015, © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC. © 2015, © Yibin Deng and Junxuan Lu.


  • CRPC
  • HK2
  • PTEN
  • Warburg effect
  • p53


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