Targeting eukaryotic protein translation in mesothelioma

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

The default mechanism for protein translation in eukaryotes involves activation of the eIF4 complex at the 5' end of mRNA. This activity is upregulated in cancers, resulting in the expression of a variety of proteins necessary for the development and maintenance of the neoplastic state. Not surprisingly, mesothelioma demonstrates this same reliance on activation of 5' cap mediated translation. Efforts are ongoing to target and exploit our knowledge of this key molecular switch for cancer therapy. Agents targeting the critical eIF4E cap binding protein, disruption of the eIF4 complex, and exploitation for oncolytic virotherapy are some of the important areas of current research in mesothelioma protein translational research.

Original languageEnglish (US)
Pages (from-to)343-349
Number of pages7
JournalTranslational Lung Cancer Research
Volume6
Issue number3
DOIs
StatePublished - Jun 1 2017

Fingerprint

Mesothelioma
Protein Biosynthesis
Oncolytic Virotherapy
RNA Cap-Binding Proteins
Translational Medical Research
Eukaryota
Neoplasms
Proteins
Maintenance
Messenger RNA
Research
Therapeutics

Keywords

  • Eukaryotic initiation factor 4 (eIF4)
  • Eukaryotic initiation factor 4E (eIF4E)
  • Protein
  • Translation; mesothelioma

Cite this

Targeting eukaryotic protein translation in mesothelioma. / Kratzke, Robert A.

In: Translational Lung Cancer Research, Vol. 6, No. 3, 01.06.2017, p. 343-349.

Research output: Contribution to journalReview article

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