Targeting drug sensitivity predictors: New potential strategies to improve pharmacotherapy of human brain disorders

Allan V. Kalueff, Adam Michael Stewart, Michael Nguyen, Cai Song, Irving I. Gottesman

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

One of the main challenges in medicine is the lack of efficient drug therapies for common human disorders. For example, although depressed patients receive powerful antidepressants, many often remain resistant to psychopharmacotherapy. The growing recognition of complex interplay between the drug targets and the predictors of drug sensitivity requires an improved understanding of these two key aspects of drug action and their potentially shared molecular networks. Here, we apply the concept of endophenotypes and their interplay to drug action and sensitivity. Based on these analyses, we postulate that novel drugs may be developed by targeting specific molecular pathways that integrate drug targets with drug sensitivity predictors.

Original languageEnglish (US)
Pages (from-to)76-82
Number of pages7
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume63
DOIs
StatePublished - Dec 3 2015

Bibliographical note

Funding Information:
This study is supported by the ZENEREI Institute Intramural Research Program (AVK, AMS) , Guangdong Ocean University RIMND funds (AVK, CS), as well as the Lieber Prize for Schizophrenia Research and the University of Louisville Grawemeyer Award in Psychology (IIG) .

Publisher Copyright:
© 2015 Elsevier Inc.

Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.

Keywords

  • Drug sensitivity predictor
  • Drug target
  • Efficacy
  • Endophenotype
  • Psychopharmacotherapy

Fingerprint Dive into the research topics of 'Targeting drug sensitivity predictors: New potential strategies to improve pharmacotherapy of human brain disorders'. Together they form a unique fingerprint.

Cite this