One of the main challenges in medicine is the lack of efficient drug therapies for common human disorders. For example, although depressed patients receive powerful antidepressants, many often remain resistant to psychopharmacotherapy. The growing recognition of complex interplay between the drug targets and the predictors of drug sensitivity requires an improved understanding of these two key aspects of drug action and their potentially shared molecular networks. Here, we apply the concept of endophenotypes and their interplay to drug action and sensitivity. Based on these analyses, we postulate that novel drugs may be developed by targeting specific molecular pathways that integrate drug targets with drug sensitivity predictors.
|Original language||English (US)|
|Number of pages||7|
|Journal||Progress in Neuro-Psychopharmacology and Biological Psychiatry|
|State||Published - Dec 3 2015|
Bibliographical noteFunding Information:
This study is supported by the ZENEREI Institute Intramural Research Program (AVK, AMS) , Guangdong Ocean University RIMND funds (AVK, CS), as well as the Lieber Prize for Schizophrenia Research and the University of Louisville Grawemeyer Award in Psychology (IIG) .
© 2015 Elsevier Inc.
Copyright 2015 Elsevier B.V., All rights reserved.
- Drug sensitivity predictor
- Drug target