Targeting diastolic dysfunction by genetic engineering of calcium handling proteins

Pierre Coutu, Jennifer C. Hirsch, Michael L. Szatkowski, Joseph M. Metzger

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations


Diastolic heart failure (HF) is associated with significant morbidity and mortality, and is a growing medical problem in this country. Diastolic dysfunction is defined as an abnormality in myocardial relaxation that impairs filling during diastole and contributes to the clinical syndrome of HF. Effective clinical strategies to treat diastolic dysfunction are limited. This article focuses on the potential application of parvalbumin - a fast skeletal muscle calcium buffer - for remediation of slow relaxation in the failing heart.

Original languageEnglish (US)
Pages (from-to)63-67
Number of pages5
JournalTrends in Cardiovascular Medicine
Issue number2
StatePublished - Feb 2003

Bibliographical note

Funding Information:
This work was supported by grants from the National Institutes of Health and from the University of Michigan Center for Integrative Genomics.


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