Targeting deubiquitinating enzymes and autophagy in cancer

Ashley Mooneyham, Martina Bazzaro

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Maintenance of proper cellular homeostasis requires constant surveillance and precise regulation of intracellular protein content. Protein monitoring and degradation is performed by two distinct pathways in a cell: the autophage-lysosome pathway and the ubiquitin-proteasome pathway. Protein degradation pathways are frequently dysregulated in multiple cancer types and can be both tumor suppressive and tumor promoting. This knowledge has presented the ubiquitin proteasome system (UPS) and autophagy as attractive cancer therapeutic targets. Deubiquitinating enzymes of the UPS have garnered recent attention in the field of cancer therapeutics due to their frequent dysregulation in multiple cancer types. The content of this chapter discusses reasoning behind and advances toward targeting autophagy and the deubiquitinating enzymes of the UPS in cancer therapy, as well as the compelling evidence suggesting that simultaneous targeting of these protein degradation systems may deliver the most effective, synergistic strategy to kill cancer cells.

Original languageEnglish (US)
Pages (from-to)49-59
Number of pages11
JournalMethods in Molecular Biology
Volume1513
DOIs
StatePublished - Jan 1 2017

Fingerprint

Autophagy
Proteasome Endopeptidase Complex
Ubiquitin
Neoplasms
Proteolysis
Deubiquitinating Enzymes
Lysosomes
Homeostasis
Therapeutics
Maintenance

Keywords

  • Autophagy
  • Cancer
  • Deubiquitinating enzymes
  • Small molecule inhibitors
  • Ubiquitin-proteasome system

PubMed: MeSH publication types

  • Journal Article
  • Review

Cite this

Targeting deubiquitinating enzymes and autophagy in cancer. / Mooneyham, Ashley; Bazzaro, Martina.

In: Methods in Molecular Biology, Vol. 1513, 01.01.2017, p. 49-59.

Research output: Contribution to journalArticle

@article{719caf95f0f4440db6ba365d4af40839,
title = "Targeting deubiquitinating enzymes and autophagy in cancer",
abstract = "Maintenance of proper cellular homeostasis requires constant surveillance and precise regulation of intracellular protein content. Protein monitoring and degradation is performed by two distinct pathways in a cell: the autophage-lysosome pathway and the ubiquitin-proteasome pathway. Protein degradation pathways are frequently dysregulated in multiple cancer types and can be both tumor suppressive and tumor promoting. This knowledge has presented the ubiquitin proteasome system (UPS) and autophagy as attractive cancer therapeutic targets. Deubiquitinating enzymes of the UPS have garnered recent attention in the field of cancer therapeutics due to their frequent dysregulation in multiple cancer types. The content of this chapter discusses reasoning behind and advances toward targeting autophagy and the deubiquitinating enzymes of the UPS in cancer therapy, as well as the compelling evidence suggesting that simultaneous targeting of these protein degradation systems may deliver the most effective, synergistic strategy to kill cancer cells.",
keywords = "Autophagy, Cancer, Deubiquitinating enzymes, Small molecule inhibitors, Ubiquitin-proteasome system",
author = "Ashley Mooneyham and Martina Bazzaro",
year = "2017",
month = "1",
day = "1",
doi = "10.1007/978-1-4939-6539-7_5",
language = "English (US)",
volume = "1513",
pages = "49--59",
journal = "Methods in Molecular Biology",
issn = "1064-3745",
publisher = "Humana Press",

}

TY - JOUR

T1 - Targeting deubiquitinating enzymes and autophagy in cancer

AU - Mooneyham, Ashley

AU - Bazzaro, Martina

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Maintenance of proper cellular homeostasis requires constant surveillance and precise regulation of intracellular protein content. Protein monitoring and degradation is performed by two distinct pathways in a cell: the autophage-lysosome pathway and the ubiquitin-proteasome pathway. Protein degradation pathways are frequently dysregulated in multiple cancer types and can be both tumor suppressive and tumor promoting. This knowledge has presented the ubiquitin proteasome system (UPS) and autophagy as attractive cancer therapeutic targets. Deubiquitinating enzymes of the UPS have garnered recent attention in the field of cancer therapeutics due to their frequent dysregulation in multiple cancer types. The content of this chapter discusses reasoning behind and advances toward targeting autophagy and the deubiquitinating enzymes of the UPS in cancer therapy, as well as the compelling evidence suggesting that simultaneous targeting of these protein degradation systems may deliver the most effective, synergistic strategy to kill cancer cells.

AB - Maintenance of proper cellular homeostasis requires constant surveillance and precise regulation of intracellular protein content. Protein monitoring and degradation is performed by two distinct pathways in a cell: the autophage-lysosome pathway and the ubiquitin-proteasome pathway. Protein degradation pathways are frequently dysregulated in multiple cancer types and can be both tumor suppressive and tumor promoting. This knowledge has presented the ubiquitin proteasome system (UPS) and autophagy as attractive cancer therapeutic targets. Deubiquitinating enzymes of the UPS have garnered recent attention in the field of cancer therapeutics due to their frequent dysregulation in multiple cancer types. The content of this chapter discusses reasoning behind and advances toward targeting autophagy and the deubiquitinating enzymes of the UPS in cancer therapy, as well as the compelling evidence suggesting that simultaneous targeting of these protein degradation systems may deliver the most effective, synergistic strategy to kill cancer cells.

KW - Autophagy

KW - Cancer

KW - Deubiquitinating enzymes

KW - Small molecule inhibitors

KW - Ubiquitin-proteasome system

UR - http://www.scopus.com/inward/record.url?scp=84994222249&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84994222249&partnerID=8YFLogxK

U2 - 10.1007/978-1-4939-6539-7_5

DO - 10.1007/978-1-4939-6539-7_5

M3 - Article

VL - 1513

SP - 49

EP - 59

JO - Methods in Molecular Biology

JF - Methods in Molecular Biology

SN - 1064-3745

ER -