Targeting β-cell function early in the course of therapy for type 2 diabetes mellitus

Jack L. Leahy, Irl B. Hirsch, Kevin A. Peterson, Doron Schneider

Research output: Contribution to journalReview articlepeer-review

96 Scopus citations


Objective: This report examines current perspectives regarding likely mechanisms of β-cell failure in type 2 diabetes and their clinical implications for protecting or sparing β-cells early in the disease progression. In addition, it considers translation strategies to incorporate relevant scientific findings into educational initiatives targeting clinical practice behavior. Participants: On January 10, 2009, a working group of basic researchers, clinical endocrinologists, and primary care physicians met to consider whether current knowledge regarding pancreatic β-cell defects justifies retargeting and retiming treatment for clinical practice. Based on this meeting, a writing group comprised of four meeting participants subsequently prepared this consensus statement. The conference was convened by The Endocrine Society and funded by an unrestricted educational grant from Novo Nordisk. Evidence: Participants reviewed and discussed published literature, plus their own unpublished data. Consensus Process: The summary and recommendations were supported unanimously by the writing group as representing the consensus opinions of the working group. Conclusions: Workshop participants strongly advocated developing new systems to address common barriers to glycemic control and recommended several initial steps toward this goal. These recommendations included further studies to establish the clinical value of pharmacological therapies, continuing basic research to elucidate the nature and mechanisms of β-cell failure in type 2 diabetes mellitus, and exploring new educational approaches to promote pathophysiology-based clinical practices. The Endocrine Society has launched a new website to continue the discussion between endocrinologists and primary care physicians on β-cell pathophysiology in type 2 diabetes and its clinical implications. Join the conversation at

Original languageEnglish (US)
Pages (from-to)4206-4216
Number of pages11
JournalJournal of Clinical Endocrinology and Metabolism
Issue number9
StatePublished - Sep 2010
Externally publishedYes

Bibliographical note

Funding Information:
This paper was based on a meeting sponsored by The Endocrine Society and with the financial support of an unrestricted educational grant to The Endocrine Society from Novo Nordisk.


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