Tandem duplicate genes in maize are abundant and date to two distinct periods of time

Thomas J.Y. Kono, Alex B. Brohammer, Suzanne E. McGaugh, Candice N. Hirsch

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Tandem duplicate genes are proximally duplicated and as such occur in similar genomic neighborhoods. Using the maize B73 and PH207 de novo genome assemblies, we identified thousands of tandem gene duplicates that account for ~10% of the annotated genes. These tandem duplicates have a bimodal distribution of ages, which coincide with ancient allopolyploidization and more recent domestication. Tandem duplicates are smaller on average and have a higher probability of containing LTR elements than other genes, suggesting origins in nonhomologous recombination. Within relatively recent tandem duplicate genes, ~26% appear to be undergoing degeneration or divergence in function from the ancestral copy. Our results show that tandem duplicates are abundant in maize, arose in bursts throughout maize evolutionary history under multiple potential mechanisms, and may provide a substrate for novel phenotypic variation.

Original languageEnglish (US)
Pages (from-to)3049-3058
Number of pages10
JournalG3: Genes, Genomes, Genetics
Volume8
Issue number9
DOIs
StatePublished - Sep 1 2018

Bibliographical note

Funding Information:
This work was supported by the National Science Foundation [IOS-1546727] to CNH and SEM. ABB was supported by a DuPont Pioneer Bill Kuhn Honorary Fellowship and a MnDRIVE Global Food Ventures fellowship. The authors acknowledge the Minnesota Supercomputing Institute (MSI) at the University of Minnesota for providing resources that contributed to the research results reported within this paper http://www.msi.umn.edu.

Keywords

  • Copy number variation
  • Genome evolution
  • Maize
  • Tandem duplicate
  • Transposable element

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