Tandem allylboration-ring-closing metathesis reactions for the preparation of biologically active molecules

P. Veeraraghavan Ramachandran, M. Venkat Ram Reddy, Herbert C. Brown

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

The development of asymmetric synthesis during the past two decades aided organic chemists considerably in the synthesis of complex natural products. Organoborane chemistry continues to play an important role in asymmetric synthesis. One of the important reactions that has become very common in the arsenal of synthetic chemists is allylboration and related reactions. Another important reaction that has recently attained enormous importance in organic chemistry is the ring-closing metathesis (RCM) reaction. Indeed, a combination of allylboration and RCM reactions provides an excellent route to cyclic ethers, lactones, lactams, etc. Herein, we describe a sequential asymmetric allylboration and RCM reaction protocol that has been utilized for the synthesis of several α-pyrone-containing natural products, particularly biologically active molecules.

Original languageEnglish (US)
Pages (from-to)1263-1275
Number of pages13
JournalPure and Applied Chemistry
Volume75
Issue number9
DOIs
StatePublished - Sep 1 2003

Fingerprint Dive into the research topics of 'Tandem allylboration-ring-closing metathesis reactions for the preparation of biologically active molecules'. Together they form a unique fingerprint.

Cite this