Taking the route less traveled: on the way to COpAT

Margaret Pertzborn, Christina G. Rivera, Don Bambino Geno Tai

Research output: Contribution to journalReview articlepeer-review


Antimicrobial therapy is an essential practice within medicine. Over the last 4 years, complex outpatient antimicrobial therapy (COpAT) with oral antimicrobials has become a rapidly developing area of practice and is non-inferior to outpatient parenteral antimicrobial therapy (OPAT) in certain infectious syndromes. Currently, the available literature does not describe the implementation of oral antimicrobials within the current outpatient antimicrobial therapy process. Throughout this article, the authors present a review of current literature, a proposed definition of COpAT and offer methods readers can utilize to implement an integrated COpAT/OPAT program with oral antimicrobial-specific monitoring within their current practice.

Original languageEnglish (US)
JournalTherapeutic Advances in Infectious Disease
StatePublished - Jan 1 2023

Bibliographical note

Publisher Copyright:
© The Author(s), 2023.


  • COpAT
  • OPAT
  • antimicrobial therapy
  • artificial intelligence
  • bone and joint infections
  • complex outpatient antimicrobial therapy
  • endocarditis
  • oral antibiotics

PubMed: MeSH publication types

  • Journal Article
  • Review


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