Tail pinch behavior and analgesia in diabetic mice

Allen S Levine, John E. Morley, George L Wilcox, David M. Brown, Barry S. Handwerger

Research output: Contribution to journalArticlepeer-review

53 Scopus citations


Mild tail pinch induced "consummatory" behaviors in mice. The major tail pinch behavior appeared to be chewing with food ingestion occurring possibly as an epiphenomenon. All tail pinch behaviors were obliterated by the dopamine antagonist haloperidol; and the opiate antagonist, naltrexone, decreased eating without altering chewing. The combination of dopamine blockade and tail pinch induced jumping behavior in mice. Diabetic mice showed increased tail flick latencies to radiant heat and to the induction of tail pinch behaviors, displaying these behaviors less commonly than their homozygote and heterozygote littermate controls.

Original languageEnglish (US)
Pages (from-to)39-43
Number of pages5
JournalPhysiology and Behavior
Issue number1
StatePublished - Jan 1982

Bibliographical note

Funding Information:
We thank Martha Grace and Julie Kneip for their excellent technical assistance and JoAnn Tallman for her secretarial aid. We thank Neil Rowland for his helpful comments. This work was supported by Veterans Administration Research.


  • Analgesia
  • Appetite
  • Diabetes
  • Diabetic mouse
  • Dopamine
  • Naltrexone
  • Opiates
  • Stress-induced eating


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