Tacrolimus pharmacokinetics in BMT patients

G. W. Boswell, I. Bekersky, J. Fay, J. Wingard, J. Antin, D. Weisdorf, R. Maher, W. Fitzsimmons, R. Nash

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34 Scopus citations

Abstract

The pharmacokinetics of tacrolimus following its administration as monotherapy or in combination with corticosteroids or methotrexate to 31 BMT patients are presented. All patients received i.v. tacrolimus initially and were subsequently switched to p.o. dosing. Patients received methotrexate by i.v. bolus on post-transplantation days 1, 3, 6 and 11. Patients were started on i.v. corticosteroids beginning on post-transplantation day 7. The noncompartmental pharmacokinetics of tacrolimus based on whole blood concentrations were determined following the i.v. and p.o. doses and were not different at steady-state compared to a single dose. The mean terminal elimination half-life of tacrolimus was 18.2 h following i.v. administration; the total body clearance was 71 ml/h/kg, the volume of distribution was 1.67 l/kg. Coadministration of methylprednisolone or methotrexate did not significantly alter tacrolimus pharmacokinetics. The p.o. bioavailabiiity was 31-49%. Trough blood concentrations (C(min)) at 0 h (pre-dose) and 12 h (post-dose) correlated well to AUC0-12 indicating that, as in solid organ transplantation, C(min) was a good index of drug exposure. Correlation at 0 h (r = 0.92) and at 12 h (r = 0.93) indicate that either time point can be used for therapeutic drug monitoring in patient management.

Original languageEnglish (US)
Pages (from-to)23-28
Number of pages6
JournalBone marrow transplantation
Volume21
Issue number1
DOIs
StatePublished - Jan 1 1998

Keywords

  • Bone marrow transplant
  • Corticosteroids
  • Methotrexate
  • Pharmacokinetics
  • Tacrolimus (FK506)

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