TY - JOUR
T1 - Tablets of multi-unit pellet system for controlled drug delivery
AU - Chen, Tongkai
AU - Li, Jian
AU - Chen, Ting
AU - Sun, Changquan Calvin
AU - Zheng, Ying
N1 - Publisher Copyright:
© 2017
PY - 2017/9/28
Y1 - 2017/9/28
N2 - The tablet of multi-unit pellet system (TMUPS), using coated pellets, for controlled release of drugs is an effective therapeutic alternative to conventional immediate-release dosage forms. The main advantages of TMUPS include a) ease of swallowing and b) divisible without compromising the drug release characteristics of the individual units. TMUPS can be prepared more economically than pellet-filled capsules because of the much higher production rate of tableting process. In spite of the superiorities of TMUPS, its adoption has been challenged by manufacturing problems, such as compromised integrity of coated pellets and poor content uniformity. Herein, we provide an updated review on research, from both scientific literatures and patents, related to the compaction of TMUPS. Factors important for the successful production of TMUPS are summarized, including model drug property, potential cushioning agents, and novel techniques to protect pellets from damage. This review is intended to facilitate the future development of manufacturable TMUPS with drug release behavior similar to that of the original coated pellets.
AB - The tablet of multi-unit pellet system (TMUPS), using coated pellets, for controlled release of drugs is an effective therapeutic alternative to conventional immediate-release dosage forms. The main advantages of TMUPS include a) ease of swallowing and b) divisible without compromising the drug release characteristics of the individual units. TMUPS can be prepared more economically than pellet-filled capsules because of the much higher production rate of tableting process. In spite of the superiorities of TMUPS, its adoption has been challenged by manufacturing problems, such as compromised integrity of coated pellets and poor content uniformity. Herein, we provide an updated review on research, from both scientific literatures and patents, related to the compaction of TMUPS. Factors important for the successful production of TMUPS are summarized, including model drug property, potential cushioning agents, and novel techniques to protect pellets from damage. This review is intended to facilitate the future development of manufacturable TMUPS with drug release behavior similar to that of the original coated pellets.
KW - Coating
KW - Cushioning agents
KW - Drug delivery system (DDS)
KW - Multi-unit pellet system (MUPS)
KW - Pellets
KW - Tableting of pellets
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U2 - 10.1016/j.jconrel.2017.07.043
DO - 10.1016/j.jconrel.2017.07.043
M3 - Review article
C2 - 28774838
AN - SCOPUS:85026788539
SN - 0168-3659
VL - 262
SP - 222
EP - 231
JO - Journal of Controlled Release
JF - Journal of Controlled Release
ER -