Tabletability Modulation Through Surface Engineering

Frederick Osei-Yeboah, Changquan Calvin Sun

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Poor powder tabletability is a common problem that challenges the successful development of high-quality tablet products. Using noncompressible microcrystalline cellulose beads, we demonstrate that surface coating is an effective strategy for modulating tabletability, almost at will, through judicious selection of coating material. This strategy has broad applicability as tabletability of such particles is dictated by the properties of the outermost layer coat regardless the nature of the core.

Original languageEnglish (US)
Pages (from-to)2645-2648
Number of pages4
JournalJournal of Pharmaceutical Sciences
Volume104
Issue number8
DOIs
StatePublished - Aug 1 2015

Keywords

  • compaction
  • compression
  • fluid-bed
  • hardness
  • materials science
  • polymers
  • polyvinylpyrrolidone
  • powder technology
  • tablet

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