Tabletability Flip – Role of Bonding Area and Bonding Strength Interplay

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Predicting tableting performance of mixtures from that of individual components is of practical importance for achieving efficient and robust tablet design. It has been commonly assumed that a solid form exhibiting better tabletability will result in better tabletability when formulated. However, we show that the rank order of tabletability between two powders can flip when mixed with another powder, a phenomenon termed tabletability flip. Using three examples, we show that the tabletability flip upon mixing with microcrystalline cellulose is activated by the switch of the dominating factor in the bonding area (BA) and bonding strength (BS) interplay that determines tablet tensile strength. A mechanistic understanding of this phenomenon can significantly improve the accuracy of predicted tableting performance of mixtures from that of individual powders.

Original languageEnglish (US)
Pages (from-to)3569-3573
Number of pages5
JournalJournal of Pharmaceutical Sciences
Issue number12
StatePublished - Dec 2020

Bibliographical note

Funding Information:
This work is supported by the Dane O. Kildsig Center for Pharmaceutical Processing Research (CPPR).

Publisher Copyright:
© 2020 American Pharmacists Association®

Copyright 2021 Elsevier B.V., All rights reserved.


  • Bonding area
  • Bonding strength
  • Mixture
  • Plasticity
  • Tabletability flip

PubMed: MeSH publication types

  • Journal Article
  • Research Support, Non-U.S. Gov't


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