T-lymphocyte interactions with endothelium and extracellular matrix

Stephen W. Hunt, Estelle S. Harris, Sirid Aimée Kellermann, Yoji Shimizu

Research output: Contribution to journalReview article

16 Citations (Scopus)

Abstract

T-lymphocyte movement out of the bloodstream and into tissue is critical to the success of these cells in their role in immunosurveillance. This process involves interactions of the T-cell with endothelium as well as with extracellular matrix. Central to these interactions are a number of T-cell adhesion molecules and their endothelial and extracellular matrix ligands. The identification and functional characterization of adhesion molecules have been the subject of intensive research in recent years. We highlight here the latest developments in this rapidly expanding field as they pertain to T- cell interactions with endothelial cells and extracellular matrix components, including: (1) identification of adhesion molecule families, including the selectins, mucins, integrins, immunoglobulin superfamily members, and cadherins; (2) elucidation of the multi-step adhesion cascade that mediates the rolling, arrest, and eventual diapedesis of T-cells through the vascular endothelium into the surrounding tissue; (3) the changes in adhesion molecule expression that accompany T-cell maturation and activation, and the impact of those changes on T-cell migration; (4) the functional relevance of the extracellular matrix for T-cell function; and (5) the clinical relevance of adhesion molecules and the potential for targeting these molecules for the amelioration of immune-mediated diseases.

Original languageEnglish (US)
Pages (from-to)59-86
Number of pages28
JournalCritical Reviews in Oral Biology and Medicine
Volume7
Issue number1
DOIs
StatePublished - Jan 1 1996

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Endothelium
Extracellular Matrix
T-Lymphocytes
Transendothelial and Transepithelial Migration
Immunologic Monitoring
Selectins
Immune System Diseases
Vascular Endothelium
Cell Adhesion Molecules
Mucins
Cadherins
Integrins
Cell Communication
Cell Movement
Immunoglobulins
Endothelial Cells
Ligands
Research

Keywords

  • Cell adhesion
  • endothelium
  • extracellular matrix
  • integrin
  • selectin

Cite this

T-lymphocyte interactions with endothelium and extracellular matrix. / Hunt, Stephen W.; Harris, Estelle S.; Kellermann, Sirid Aimée; Shimizu, Yoji.

In: Critical Reviews in Oral Biology and Medicine, Vol. 7, No. 1, 01.01.1996, p. 59-86.

Research output: Contribution to journalReview article

Hunt, Stephen W. ; Harris, Estelle S. ; Kellermann, Sirid Aimée ; Shimizu, Yoji. / T-lymphocyte interactions with endothelium and extracellular matrix. In: Critical Reviews in Oral Biology and Medicine. 1996 ; Vol. 7, No. 1. pp. 59-86.
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