T-cell selection

Stephen C. Jameson, Michael J. Bevan

Research output: Contribution to journalArticlepeer-review

132 Scopus citations

Abstract

Major histocompatibility complex (MHC) molecules in the thymus select from the repertoire of germline receptors those that will be most useful in mounting responses to antigen in the periphery. Recent data has shed light on the involvement of self peptides presented by the MHC in this process, and has indicated that a requirement for the constant recognition of 'self' may be essential for T-cell longevity in the periphery.

Original languageEnglish (US)
Pages (from-to)214-219
Number of pages6
JournalCurrent Opinion in Immunology
Volume10
Issue number2
DOIs
StatePublished - Apr 1998

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