Resident memory CD8 t cells trigger protective innate and adaptive immune responses

Jason M Schenkel, Kathryn A Fraser, Lalit K Beura, Kristen E. Pauken, Vaiva Vezys, David Masopust

Research output: Contribution to journalArticlepeer-review

427 Scopus citations

Abstract

The pathogen recognition theory dictates that, upon viral infection, the innate immune system first detects microbial products and then responds by providing instructions to adaptive CD8 T cells. Here, we show in mice that tissue resident memory CD8 T cells (TRM cells), non-recirculating cells located at common sites of infection, can achieve near-sterilizing immunity against viral infections by reversing this flow of information. Upon antigen resensitization within the mouse female reproductive mucosae, CD8+ TRM cells secrete cytokines that trigger rapid adaptive and innate immune responses, including local humoral responses, maturation of local dendritic cells, and activation of natural killer cells. This provided near-sterilizing immunity against an antigenically unrelated viral infection. Thus, CD8+ TRM cells rapidly trigger an antiviral state by amplifying receptor-derived signals from previously encountered pathogens.

Original languageEnglish (US)
Pages (from-to)98-101
Number of pages4
JournalScience (New York, N.Y.)
Volume346
Issue number6205
DOIs
StatePublished - Oct 3 2014

Bibliographical note

Publisher Copyright:
Copyright © 2014 by the American Association for the Advancement of Science; all rights reserved.

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