Abstract
Immune responses to infection or effective vaccination generally result in the development of memory lymphocytes capable of mounting a rapid response to secondary infection. Since most infections initiate in non-lymphoid tissues, defense at these sites may be important for protection. Recent results suggest that a substantial portion of the T cell response to infection is focused in non-lymphoid tissues. Furthermore, anatomic localization appears to define phenotypic and functional heterogeneity among antigen-specific memory T cell populations.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 503-508 |
| Number of pages | 6 |
| Journal | Current Opinion in Immunology |
| Volume | 14 |
| Issue number | 4 |
| DOIs | |
| State | Published - Aug 1 2002 |
Bibliographical note
Funding Information:The work described from our laboratory was supported by the National Institutes of Health. We would like to thank the members of the laboratory for many insightful discussions.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.