T cell immunity in lymphoid and non-lymphoid tissues

Leo Lefrançois, David Masopust

Research output: Contribution to journalReview articlepeer-review

98 Scopus citations


Immune responses to infection or effective vaccination generally result in the development of memory lymphocytes capable of mounting a rapid response to secondary infection. Since most infections initiate in non-lymphoid tissues, defense at these sites may be important for protection. Recent results suggest that a substantial portion of the T cell response to infection is focused in non-lymphoid tissues. Furthermore, anatomic localization appears to define phenotypic and functional heterogeneity among antigen-specific memory T cell populations.

Original languageEnglish (US)
Pages (from-to)503-508
Number of pages6
JournalCurrent Opinion in Immunology
Issue number4
StatePublished - Aug 1 2002

Bibliographical note

Funding Information:
The work described from our laboratory was supported by the National Institutes of Health. We would like to thank the members of the laboratory for many insightful discussions.

Copyright 2017 Elsevier B.V., All rights reserved.


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