T cell immunity in lymphoid and non-lymphoid tissues

Leo Lefrançois, David Masopust

Research output: Contribution to journalReview articlepeer-review

93 Scopus citations

Abstract

Immune responses to infection or effective vaccination generally result in the development of memory lymphocytes capable of mounting a rapid response to secondary infection. Since most infections initiate in non-lymphoid tissues, defense at these sites may be important for protection. Recent results suggest that a substantial portion of the T cell response to infection is focused in non-lymphoid tissues. Furthermore, anatomic localization appears to define phenotypic and functional heterogeneity among antigen-specific memory T cell populations.

Original languageEnglish (US)
Pages (from-to)503-508
Number of pages6
JournalCurrent Opinion in Immunology
Volume14
Issue number4
DOIs
StatePublished - Aug 1 2002

Bibliographical note

Funding Information:
The work described from our laboratory was supported by the National Institutes of Health. We would like to thank the members of the laboratory for many insightful discussions.

Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.

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