Immune responses to infection or effective vaccination generally result in the development of memory lymphocytes capable of mounting a rapid response to secondary infection. Since most infections initiate in non-lymphoid tissues, defense at these sites may be important for protection. Recent results suggest that a substantial portion of the T cell response to infection is focused in non-lymphoid tissues. Furthermore, anatomic localization appears to define phenotypic and functional heterogeneity among antigen-specific memory T cell populations.
|Original language||English (US)|
|Number of pages||6|
|Journal||Current Opinion in Immunology|
|State||Published - Aug 1 2002|
Bibliographical noteFunding Information:
The work described from our laboratory was supported by the National Institutes of Health. We would like to thank the members of the laboratory for many insightful discussions.
Copyright 2017 Elsevier B.V., All rights reserved.