T cell homeostasis: Keeping useful T cells alive and live T cells useful

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Abstract

It has become clear that the regulation of T cell numbers is under peripheral homeostatic control. However, the rules for homeostasis vary with the T cells' differentiation state and the overall T cell number in the animal. Furthermore, homeostatic pressures can cause unexpected changes in T cell differentiation and function which might promote or dampen T cell reactivity. In this review, we focus on the role of peptide/MHC and cytokine interactions in regulating the size and composition of the T cell pool.

Original languageEnglish (US)
Pages (from-to)231-237
Number of pages7
JournalSeminars in Immunology
Volume17
Issue number3
DOIs
StatePublished - Jun 2005

Bibliographical note

Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.

Keywords

  • Cytokines
  • Memory T cells
  • Naïve T cells
  • Peptide/MHC
  • TCR

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