T cell adolescence: Maturation events beyond positive selection

Kristin A Hogquist, Yan Xing, Fan Chi Hsu, Virginia Smith Shapiro

Research output: Contribution to journalReview article

31 Citations (Scopus)

Abstract

Single-positive thymocytes that successfully complete positive and negative selection must still undergo one final step, generally termed T cell maturation, before they gain functional competency and enter the longlived T cell pool. Maturation initiates after positive selection in single-positive thymocytes and continues in the periphery in recent thymic emigrants, before these newly produced T cells gain functional competency and are ready to participate in the immune response as peripheral naive T cells. Recent work using genetically altered mice demonstrates that T cell maturation is not a single process, but a series of steps that occur independently and sequentially after positive selection. This review focuses on the changes that occur during T cell maturation, as well as the molecules and pathways that are critical at each step.

Original languageEnglish (US)
Pages (from-to)1351-1357
Number of pages7
JournalJournal of Immunology
Volume195
Issue number4
DOIs
StatePublished - Aug 15 2015

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T-Lymphocytes
Thymocytes
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T cell adolescence : Maturation events beyond positive selection. / Hogquist, Kristin A; Xing, Yan; Hsu, Fan Chi; Shapiro, Virginia Smith.

In: Journal of Immunology, Vol. 195, No. 4, 15.08.2015, p. 1351-1357.

Research output: Contribution to journalReview article

Hogquist, Kristin A ; Xing, Yan ; Hsu, Fan Chi ; Shapiro, Virginia Smith. / T cell adolescence : Maturation events beyond positive selection. In: Journal of Immunology. 2015 ; Vol. 195, No. 4. pp. 1351-1357.
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