Systemic or Forebrain Neuron-Specific Deficiency of Geranylgeranyltransferase-1 Impairs Synaptic Plasticity and Reduces Dendritic Spine Density

Keyphrases

• Synaptic Plasticity 100%
• Brain Cells 100%
• Geranylgeranyl Transferase 100%
• Neuron-specific 100%
• Dendritic Spine Density 100%
• Cognitive Function 30%
• Farnesyltransferase 20%
• Cell Membrane 10%
• Long-term Potentiation 10%
• Alzheimer's Disease 10%
• Differential Effects 10%
• Synaptic 10%
• Density Function 10%
• Isoprenoids 10%
• Synaptic Dysfunction 10%
• Cell Behavior 10%
• Alzheimer's Disease Model 10%
• Neuropathology 10%
• Neuroinflammation 10%
• Cognitive Benefits 10%
• Small GTPase 10%
• Membrane-associated 10%
• Lysate 10%
• Detrimental Effects 10%
• Protein Farnesyltransferase 10%
• Prenylated Proteins 10%
• Cortical Neurons 10%
• CaMKII 10%
• Hippocampal Slice 10%
• HEC-RAS 10%
• Rac1 10%
• Immunoblot Analysis 10%
• Cre-loxP 10%
• Neurite Outgrowth 10%
• RhoA 10%
• Hippocampal Long-term Potentiation 10%
• Amyloid Deposition 10%
• Spine Density 10%
• Rho Family 10%
• Protein Prenyltransferases 10%
• Spinel Structure 10%
• Geranylgeranylation 10%
• Growth Plasticity 10%

Neuroscience

• Dendritic Spine 100%
• Synaptic Plasticity 100%
• Cognitive Function 100%
• Long-Term Potentiation 66%
• Vertebral Column 66%
• Alzheimer's Disease 66%
• Isoprenoid 33%
• Cell Function 33%
• Promoter Region 33%
• Neurite Outgrowth 33%
• Amyloid Protein 33%
• LoxP Site 33%
• Cell Membrane 33%
• Immunoblotting 33%