Cardiogenic shock was produced by the mercury embolization technique in closed chest anesthetized dogs. Hemodynamics and flow in the renal, superior mesenteric, and femoral arteries were measured serially for 3 hr after embolization. Mean arterial pressure fell 34% and cardiac output 44% by 30 min, whereas total peripheral resistance was increased only 7%. A 60 min. total peripheral resistance began rising significantly to 114% (P < 0.001) above control by 3 hr. Cardiac output fell further at this time to 66% (P < 0.001) below control after 3 hr. Superior mesenteric arterial flow fell significantly (21%, P < 0.01) in the first 15 min, and continued dropping parallel to cardiac output thereafter. Superior mesenteric resistance did not rise until 2 hr after infarction but rose to 96% (P < 0.02) above control level by 3 hr. Renal arterial flow was unchanged after 30 min, whereas renal resistance was reduced; flow subsequently fell progressively as resistance increased. Femoral arterial flow and resistance were not changed significantly. An early phase of inhibited vasoconstriction in experimental cardiogenic shock is followed by a period of marked vasoconstriction associated with generalized circulatory deterioration.
|Original language||English (US)|
|Number of pages||7|
|State||Published - Jan 1 1974|