TY - JOUR
T1 - Systematic Review of Prevalence of Histoplasma Antigenuria in Persons with HIV in Latin America and Africa
AU - Sekar, Preethiya
AU - Hale, Gila
AU - Gakuru, Jane
AU - Meya, David B.
AU - Boulware, David R.
AU - Ellis, Jayne
AU - Nalintya, Elizabeth
AU - Bahr, Nathan C.
AU - Rajasingham, Radha
N1 - Publisher Copyright:
© 2024 Centers for Disease Control and Prevention (CDC). All rights reserved.
PY - 2024/8
Y1 - 2024/8
N2 - Histoplasmosis is a fungal disease associated with substantial mortality rates among persons with advanced HIV disease. Our systematic review synthesized data on the global prevalence of Histoplasma-caused antigenuria in persons with HIV. We searched PubMed/ Medline, Embase, and Scopus databases on January 3, 2023, to identify cross-sectional and cohort studies evaluating Histoplasma antigenuria prevalence among adults with HIV infection. We calculated point estimates and 95% CIs to summarize prevalence. Of 1,294 studies screened, we included 15. We found Histoplasma antigenuria among 581/5,096 (11%; 95% CI 11%–12%) persons with HIV and 483/3,789 persons with advanced HIV disease (13%; 95% CI 12%–14%). Among persons with HIV and symptoms consistent with histoplasmosis, Histoplasma antigenuria prevalence was 14% (95% CI 13%–15%; 502/3,631 participants). We determined that persons with advanced HIV disease, inpatients, and symptomatic persons might benefit from a systematic approach to early detection of histoplasmosis using urine antigen testing.
AB - Histoplasmosis is a fungal disease associated with substantial mortality rates among persons with advanced HIV disease. Our systematic review synthesized data on the global prevalence of Histoplasma-caused antigenuria in persons with HIV. We searched PubMed/ Medline, Embase, and Scopus databases on January 3, 2023, to identify cross-sectional and cohort studies evaluating Histoplasma antigenuria prevalence among adults with HIV infection. We calculated point estimates and 95% CIs to summarize prevalence. Of 1,294 studies screened, we included 15. We found Histoplasma antigenuria among 581/5,096 (11%; 95% CI 11%–12%) persons with HIV and 483/3,789 persons with advanced HIV disease (13%; 95% CI 12%–14%). Among persons with HIV and symptoms consistent with histoplasmosis, Histoplasma antigenuria prevalence was 14% (95% CI 13%–15%; 502/3,631 participants). We determined that persons with advanced HIV disease, inpatients, and symptomatic persons might benefit from a systematic approach to early detection of histoplasmosis using urine antigen testing.
UR - http://www.scopus.com/inward/record.url?scp=85199397020&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85199397020&partnerID=8YFLogxK
U2 - 10.3201/eid3008.231710
DO - 10.3201/eid3008.231710
M3 - Article
C2 - 39043389
AN - SCOPUS:85199397020
SN - 1080-6040
VL - 30
SP - 1523
EP - 1530
JO - Emerging infectious diseases
JF - Emerging infectious diseases
IS - 8
ER -
