Systematic evaluation of common lubricants for optimal use in tablet formulation

Shubhajit Paul, Changquan Calvin Sun

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

As an essential formulation component for large-scale tablet manufacturing, the lubricant preserves tooling by reducing die-wall friction. Unfortunately, lubrication also often results in adverse effects on tablet characteristics, such as prolonged disintegration, slowed dissolution, and reduced mechanical strength. Therefore, the choice of lubricant and its optimal concentration in a tablet formulation is a critical decision in tablet formulation development to attain low die-wall friction while minimizing negative impact on other tablet properties. Three commercially available tablet lubricants, i.e., magnesium stearate, sodium stearyl fumerate, and stearic acid, were systematically investigated in both plastic and brittle matrices to elucidate their effects on reducing die-wall friction, tablet strength, tablet hardness, tablet friability, and tablet disintegration kinetics. Clear understanding of the lubrication efficiency of commonly used lubricants as well as their impact on tablet characteristics would help future tablet formulation efforts.

Original languageEnglish (US)
Pages (from-to)118-127
Number of pages10
JournalEuropean Journal of Pharmaceutical Sciences
Volume117
DOIs
StatePublished - May 30 2018

Keywords

  • Disintegration
  • Friability
  • Lubrication
  • Mechanical property
  • Tablet compression

Fingerprint Dive into the research topics of 'Systematic evaluation of common lubricants for optimal use in tablet formulation'. Together they form a unique fingerprint.

  • Cite this